Kontexte, Blickwinkel, Sichtachsen und Perspektivwechsel Was wir machen Das Internet sollte Zugang zu Wissen organisieren und ist ein Werkzeug zum Austausch von Ideen, Visionen und Lösungen. – Suug Productions kreiert Projekte mit Sinn – und dem Anspruch, die Welt durch neue und ungewöhnliche Kontexte, Blickwinkel, Sichtachsen und Perspektivwechsel zu einem etwas reizvolleren Ort zu machen.
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Prometheus Publishers is a Dutch publisher that publishes a wide variety of quality fiction and non-fiction titles. Prometheus’s catalogue balances established talents with new voices that we introduce into the literary market. Amongst our fiction authors are renowned Dutch-language authors such as Connie Palmen, Griet Op de Beeck, Tom Lanoye, Tim Krabbé, and Esther Verhoef. Prometheus also publishes the Dutch translations of great international voices like Umberto Eco, Sandro Veronesi, Margaret Atwood, and Zadie Smith. Our non-fiction catalogue is filled with experts from across the scientific spectrum. Ranging from history to psychology and from physics to literary studies, Prometheus offers exciting new insights into a wide range of disciplines. Prometheus also publishes a philosophical series with musings on subjects that are relevant to our society today.
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Rabbits have many uses - as well as being cherished pets, they are bred for their meat and fur, and as laboratory animals. Understanding their genetics and genomics is key to their production and, equally, to their care, welfare and health. Beginning with an introduction to the rabbit, including key information on their evolution, domestication and breed types, this book then concentrates on the genetics and genomics of this valuable animal.This book covers:- Cytogenetics, genetic maps and QTL mapping;- Immunogenetics;- Genetics of coat colour, meat, fibre and fur production, reproduction, disease resistance and more.Concluding with practical applications such as creating transgenic and genome edited rabbits, biotechnical applications and the rabbit as a biomedical model, this book brings this important topic fully up-to-date. It provides an indispensable resource for animal and veterinary researchers and students, as well as rabbit breeders and laboratory scientists. Chapter 1: The Evolution, Domestication and World Distribution of the European Rabbit (Oryctolagus cuniculus) Chapter 2: Rabbit Breeds and Lines and Genetic Resources Chapter 3: The Genome of the European Rabbit and Genomic Tools Chapter 4: Cytogenetics, Physical and Genetic Maps and QTL Mapping in the European Rabbit Chapter 5: Immunogenetics in the Rabbit Chapter 6: Genetics and Molecular Genetics of Coat Colour in the European Rabbit Chapter 7: Genetics of Fibre and Fur Production in Rabbits Chapter 8: Genetics and Molecular Genetics of Morphological and Physiological Traits and Inherited Disorders in the European Rabbit Chapter 9: Genetics of Disease Resistance in the European Rabbit Chapter 10: Genetics and Genomics of Growth, Carcass and Meat Production Traits in Rabbits Chapter 11: Biology of Reproduction and Reproduction Technologies in the Rabbit Chapter 12: Genetics of Reproduction in the Rabbit Chapter 13: Genetic Improvement in the Meat Rabbit Chapter 14: Rabbit Research in the Post-genomic Era: Transcriptome, Proteome and Metabolome Analyses Chapter 15: Methods to Create Transgenic and Genome-edited Rabbits Chapter 16: Pluripotent Stem Cells in Rabbits Chapter 17: Biotechnology Applications in the Rabbit Chapter 18: The Rabbit as a Biomedical Model
While information on the roles and regulation of transporters for all major nutrients and metabolites in plants has increased significantly, a synthesis of this research has been lacking. Based on current research in genomics and proteomics, this book clarifies the identification and characterization of plant membrane and vacuolar transporters. Transporter functions such as mineral nutrition, cell homeostasis, storage and stress responses are examined with a focus on enhancing nutrient use efficiency in crops, and increasing crops’ ability to withstand nutrient stresses and improve nutrient storage.
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This third and final volume in the acclaimed Fish Diseases and Disorders trilogy addresses infectious diseases of finfish and shellfish caused by viruses, bacteria and fungi. Topics covered include infectious pancreatic necrosis virus, infectious hematopoictic necrosis virus, viral diseases of cold and warm-water fish, rickettsial and chlamydial infections, furunculosis, motile aeromonads, vibriosis, flavobacterial diseases and shellfish diseases. Written by experts in each discipline and updated throughout to reflect new developments in the field, including new chapters on alphaviruses, oncogenic viruses and genomics and proteomics, this is a must-have reference for fish health specialists and veterinarians, microbiologists, zoologists and researchers and students in aquaculture.
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Fish Diseases and Disorders, 2nd Editioncomprises fully updated information essential for fish health specialists, veterinarians and zoologists. Volume 1 (2006) presents protozoan and metazoan infections and molecular approaches to parasitology. Volume 2 (2010) covers non-infectious disorders, including a new chapter on the relationship between welfare issues and disorders associated with intensive fish culture. Volume 3 (2011) provides up to date information on viral, bacterial and fungal infections, and new chapters on alphaviruses, oncogenic viruses and genomics and proteomics. All three updated volumes of the acclaimed Fish Diseases and Disorders are now available to purchase together at a special price saving 20% on the individual volume prices.
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While "genomics" is becoming a household term, knowing the genome of an organism alone provides relatively little information. Between the genome and the final organism is the "transcriptome" that tells us which genes are expressed and translated into proteins in a certain cell or tissue of an organism at a given time and specific situation. The transcriptome tells you what genes are being "transcribed" at any given moment, providing the wealth of data and specificity of proteomics with the relative ease of study of genetics. Transcriptomics technology thus has myriad uses, and the goal of this book is to showcase the extraordinary diversity of ways transcriptomics can be utilised in entomological research, from basic to applied, from ecology to physiology to agricultural.
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Fasciolosis is a major global infection of livestock causing both huge losses to the agricultural community and affecting human health as a food-borne disease. Fully updated throughout, this new edition continues to cover the life cycle, biology, and development of the parasite; clinical pathology, immunology, diagnosis and vaccine development; and emergence, cause and mechanisms of drug resistance. It reviews the temperate liver fluke Fasciola hepatica, together with molecular, biochemical, control, and epidemiologial aspects of the tropical liver fluke F. gigantica. Many fundamental advances have taken place in the last two decades, but of particular importance has been the mapping of the draft genome of Fasciola. In addition, comprehensive advances in transcriptomics, proteomics and glycomics have been made, and the book therefore pays particular attention to these developments with the addition of brand-new chapters. Also covering the impact these parasites have had on the global human population, their distribution and their ecology, this book provides a comprehensive and accessible resource for scientists, researchers and students of medical and veterinary parasitology.
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Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.
Biotechnological tools supplement various conventional approaches in conservation, characterization and utilization for increasing production and productivity of agricultural and horticultural crops. The emerging field of bioinformatics is an integrated field arising from merging of biology and informatics. It is a conglomeration of various new frontiers of science like genomics, proteomics, metabolomics etc. The rich warehouse of proteome and genome information nearly doubling every year has significant implications and applications in various areas of science including agriculture, horticulture, forestry and food science. Cheminformatics is specialized to a range of problems in the field of chemistry. Chemical pesticide reduction is possible by adopting cheminformatics methods to identify naturally occurring chemical compounds in crops which act against pests. Bioinformatics has transformed the discipline of life science from a purely lab based science to an information science as well. The present book Agriculture Bioinformatics is a compilation of 17 information packed s authored by working scientists in the respective discipline. In addition to the theoretical information, practical and applied aspects to boost productivity and quality of crops are given.
The book entitledis aimed to cater to the growing demand of academia, researchers and commercial ventures. Altogether there are forty four s divided into the following broad sections like 1. Bioinformatics, Genomics and Proteomics, 2. Phylogeny 3. Drug Design and Epigenomics 4. Advanced Computational Tools and Techniques 5. Statistical methods for computational biology, data mining and visualization 6. Socio Economics and Ethics. This book presents the foundations of key problems in computational molecular biology and bioinformatics. It contains basic molecular biology concepts, tools, techniques and ways to measure sequence similarity, presents simple applications of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of gene expression and motif finding. Interestingly, it is attempted to introduce computational biology without formulas that presents the biological and computational ideas in a relatively simple manner. It focuses on computational and statistical principles applied to genomes, and introduces the computational statistics that are crucial for understanding and visualization of problems. This makes the material accessible to Statistician and computer scientists without biological training, as well as to biologists with limited background in Statistics and computer science. Furthermore one has been exclusively devoted to computational biology and computational statistics as applied in biotechnology illustrated with methodology, application and interpretation of results. More than four hundred figures, illustrations and diagrams reinforce concepts and present key results from the primary literature that will be very much useful to grasp on the subject, visualize the output and make right interpretation of the result. The book will be useful for all those working in Biotechnology sector in general and particularly researchers working in the laboratories of ICAR, CSIR, SAUs and many more institutions engaged R&D activities.
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This book provides a comprehensive overview of plant omics and big data in the fields of plant and crop biology. It discusses each omics layer individually, including genomics, transcriptomics, proteomics, and covers model and non-model species. In a section on advanced topics, it considers developments in each specialized domain, including genome editing and enhanced breeding strategies (such as genomic selection and high-throughput phenotyping), with the aim of providing tools to help tackle global food security issues. The importance of online resources in big data biology are highlighted in a section summarizing both wet- and dry-biological portals. This section introduces biological resources, datasets, online bioinformatics tools and approaches that are in the public domain. This title: reviews each omics layer individually; focuses on new advanced research domains and technology; and summarizes publicly available experimental and informatics resources. This book is for students, engineers, researchers and academics in plant biology, genetics, biotechnology and bioinformatics.
The patenting and licensing of human genetic material and proteins represents an extension of intellectual property (IP) rights to naturally occurring biological material and scientific information, much of it well upstream of drugs and other disease therapies. This report concludes that IP restrictions rarely impose significant burdens on biomedical research, but there are reasons to be apprehensive about their future impact on scientific advances in this area. The report recommends 13 actions that policy-makers, courts, universities, and health and patent officials should take to prevent the increasingly complex web of IP protections from getting in the way of potential breakthroughs in genomic and proteomic research. It endorses the National Institutes of Health guidelines for technology licensing, data sharing, and research material exchanges and says that oversight of compliance should be strengthened. It recommends enactment of a statutory exception from infringement liability for research on a patented invention and raising the bar somewhat to qualify for a patent on upstream research discoveries in biotechnology. With respect to genetic diagnostic tests to detect patient mutations associated with certain diseases, the report urges patent holders to allow others to perform the tests for purposes of verifying the results.
The book deals with various tools and applications of bioinformatics in the fields of: o agriculture, corals, structural bioinformatics, data-mining, text-mining; o medicinal plants, antibiotics, protein structure prediction, drug design; o gene expression, micro-arrays, proteomics, molecular phylogenic location of the Indian Liver Fluke, rough sets to predict protein structural class; o artificial neural networks for prediction of amino acids levels, plant systems biology, molecular modeling, homology modeling, bio-efficacy of indigenous bacillus through in-silico approach; o fresh aquaculture and fisheries, pesticides and insecticides, databases and tools development in the relevant area. The book would be of much use to the person working in the field of agricultural biotechnology, bioinformatics, computer science and applied statistics.
The book throws insights on the concepts of origin and domestication of spice crops. There are elaborative description regarding different modes of reproduction of plants along with crop specific techniques regarding emasculation and pollination techniques. Conventional plant breeding methods has categorically been explained as these concepts would help spice breeders to choose the appropriate breeding tool. Detailed idea from tissue culture to genomics assisted breeding especially the theory and applications of various omics viz., metabolomics, genomics, transcriptomics, proteomics, etc., has been elaborated. Finally, different spice breeding information has been comprehensively documented in this book with some useful references to future directions of spice breeding throughout the world. The book shall pave the way for new age researchers, faculties, plant breeders, policy makers and amateur readers towards theoretical and empirical studies as well.
The objective of this book is to provide state-of-the-art knowledge, and highlight the current developments taking place in biological sciences. The book encompasses topics on prokaryotic cyanobacteria to higher plants, distributed in fourteen chapters for the benefit of graduate and post-graduate students as well as young researchers and scientists. Subjects covered include molecular and biochemical diversity of microbes, stress biology, cyanotoxins, antimicrobial activity of drugs originated from plants, natural bioactive compounds of microbial origin, detection approaches for genetically modified crops, genomics and proteomics. The book provides an insight for future perspectives in particular field with extensive bibliographies at the end of each . With all these, this book becomes highly useful and must-read for students, researchers and professionals in botany, biotechnology, bioinformatics, environmental sciences, agriculture, molecular biology and other streams of biological sciences.
This book describes and evaluates animal biotechnology and its application in veterinary medicine and pharmaceuticals as well as improvement in animal food production. Transgenic technologies are used for improving milk production and the meat in farm animals as well as for creating models of human diseases. Transgenic animals are used for the production of proteins for human medical use. Biotechnology is applied to facilitate xenotransplantation from animals to humans. Genetic engineering is done in farm animals and nuclear transfer technology has become an important and preferred method for cloning animals. Biotechnology has potential applications in the management of several animal diseases such as foot-and-mouth disease, classical swine fever, avian flue and bovine spongiform encephalopathy. The most important biotechnology based products consist of vaccines, particularly genetically engineered or DNA vaccines. Gene therapy for diseases of pet animals is a fast developing area because many of the technologies used in clinical trials humans were developed in animals and many of the diseases of cats and dogs are similar to those in humans. RNA interference technology is now being applied for research in veterinary medicine. Molecular diagnosis is assuming an important place in veterinary practice. Polymerase chain reaction and its modifications are considered to be important. Fluorescent in situ hybridization and enzyme-linked immunosorbent assays are also widely used. Newer biochip-based technologies and biosensors are also finding their way in veterinary diagnostics. This book is an attempt to unravel the mysteries of biotechnology as it affects animal health and production."
This volume of 30 chapters contributed by reputed authors covers: Diversification of livestock and crops. Integration of livestock systems with forestry and crop production. Drought and heat wave tolerant varieties. Strategies for reduction of Green House Gases emission from ruminants. Application of GIS and remote sensing technologies. Breeds with inherent genetic capabilities to adapt to climate change. This book also takes into account the climate change adaptation, mitigation practices, and policy frameworks for promotion of sustainable livestock and poultry production.
WHY SO MUCH OF SCIENCE IS WRONG! Barrie Condon shows that science is broken Science is everywhere, our medicines, our transport, what we eat and drink. Like it or not, we can’t make real progress without it. There’s just one dilemma ... What if there are profound problems with all aspects of scien fi c theory and methods? Could it be that the idea of universal laws underpinning reality is a falsehood and, as a result, we need more and more scien sts, and more and more compu ng power, to produce greater and greater elabora ons of our theories to make them fi t inconvenient experimental data? For the fi rst me, we have a book that dares to summarise these profound concerns in a way that is accessible to the general reader, who lacks a scien fi c background. It also provides a warning to Mankind of the risks we run by not acknowledging the, o en, hollow founda ons on which science is built.
Bimonthly - 2013 Volume(s) - 4 www.circgenetics.ahajournals.org Circulation: Cardiovascular Genetics publishes articles related to research in human cardiovascular genetics, including studies on Mendelian disorders and complex cardiovascular traits and disorders. Research incorporates the latest clinically relevant analytical modalities (such as haplotype maps), genome-wide association studies, transcriptomics, proteomics, and metabolomics (biomarkers), and their application to diagnostics, prognostics, and therapeutics in genetic determined cardiovascular diseases. The scope of the journal extends well beyond cardiovascular genetics, with studies evaluating genomics, proteomics, metabolomics, and biomarkers as well. Reports of clinical trials using genetic and other biomarkers are regularly featured.
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Dramatic developments in understanding the fundamental underpinnings of life have provided exciting opportunities to make marine bioproducts an important part of the U.S. economy. Several marine based pharmaceuticals are under active commercial development, ecosystem health is high on the public's list of concerns, and aquaculture is providing an ever greater proportion of the seafood on our tables. Nevertheless, marine biotechnology has not yet caught the public's, or investor's, attention. Two workshops, held in October 1999 and November 2001 at the National Academies, were successful in highlighting new developments and opportunities in environmental and biomedical applications of marine biotechnology, and also in identifying factors that are impeding commercial exploitation of these products. This report includes a synthesis of the 2001 sessions addressing drug discovery and development, applications of genomics and proteomics to marine biotechnology, biomaterials and bioengineering, and public policy and essays contributed by the workshop speakers.
