Medicine

Antimicrobial Peptides

Discovery, Design and Novel Therapeutic Strategies

by Guangshun Wang

Description

Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.

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Foreign rights available. We will positively consider translations of abridged versions of this title. If you wish to receive image and/or design files, please let us know at the beginning of the process and when making an offer. CABI reserves the right to charge an additional fee for such requests, which will be added to the overall fee, and to refuse such requests if the files are not available or for any other reason.

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Author Biography

- Dr. Guangshun Wang is an associate professor in the Department of Pathology and Microbiology at the University of Nebraska Medical Center (UNMC), Omaha, USA. He obtained his Ph.D. in Biophysical Chemistry from Simon Fraser University, Canada in 1997. During his postdoctoral stints at the Florida State University and at the National Institutes of Health (USA), he studied 3D structures of bacterial signal-transducing protein-protein complexes by multidimensional NMR spectroscopy. His current research interests at UNMC include structural, bioinformatic, and functional studies of host defense antimicrobial peptides and their potential applications that benefit human beings and agriculture, including both plants and animals. For this purpose, his laboratory created in 2003, and has been maintaining, the Antimicrobial Peptide Database (http://aps.unmc.edu/AP), a widely utilized tool for research and education in the field. Dr. Wang has edited three books, obtained four patents and p

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Bibliographic Information

  • Publisher CAB International
  • Publication Date September 2017
  • Orginal LanguageEnglish
  • ISBN/Identifier 9781786390394 / 1786390396
  • Publication Country or regionUnited Kingdom
  • FormatHardback
  • Primary Price 105 GBP
  • Pages288
  • ReadershipProfessional and Scholarly
  • Publish StatusPublished
  • Edition2
  • Copyright Year2017
  • Dimensions244 X 172 mm
  • Reference Code3873

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