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      • Trusted Partner
        Parasitology (non-medical)
        June 2013

        Parasitic Nematodes

        Molecular Biology, Biochemistry and Immunology

        by Judith E Allen, David Artis, David McK Bird, Susanne Hartmann, Collette Britton, Jonathan Ewbank, John Gilleard, Bernadette Connolly, Richard Grencis, Julian M Hopkin, Peter J Hotez, David Knox, Sara Lustigman, Rick Maizels, Aaron G Maule, Thomas B Nutman, Tony Page, Marie-Noëlle Rosso, Roger Prichard, Rupert Quinnell, Ralf Sommer, Mark Taylor, Mark Viney, Joel V Weinstock, Sarah Williams-Blangero. Edited by Malcolm W Kennedy, William Harnett.

        Covering a wide range of rapidly-developing fields of research into parasitic nematodes, this comprehensive volume discusses the genetics, biochemistry and immunology of nematode parasites of humans as well as domestic animals and plants. This fully-updated edition also covers new advances including horizontal gene transfer, immune expulsion mechanisms, genetics of susceptibility in humans, nematode protein structures, role of bacterial symbionts, intrinsic immune response, host immune system modulation, modulation of allergic and autoimmune diseases and the use of parasitic nematodes or their products as therapeutics.

      • Trusted Partner
        Medical parasitology
        June 2006

        Parasitic Flatworms

        Molecular Biology, Biochemistry, Immunology and Physiology

        by Edited by Aaron G Maule, Nikki J Marks

        Parasitic flatworms include Cestodes (tapeworms) and trematodes (flukes, schistosomes, etc) and are the cause of a number of major diseases of medical and veterinary significance. Much recent research has focused on molecular biology and genomics. this book aims to review advances in our understanding of these and related topics such as flatworm biochemistry, immunology and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. Contributors to the book include leading authorities from Europe, North and South America, and Australia.

      • Trusted Partner
        Animal husbandry
        July 2010

        Comparative Animal Nutrition and Metabolism

        by Peter Robert Cheeke, Ellen S Dierenfeld

        Nutrition is a very broad discipline, encompassing biochemistry, physiology, endocrinology, immunology, microbiology and pathology. Presenting the major principles of nutrition of both domestic and wild animals, this book takes a comparative approach, recognising that there are considerable differences in nutrient digestion, metabolism and requirements among various mammalian and avian species. Explaining species differences in food selection, food-seeking and digestive strategies and their significance to nutritional needs, chapters cover a broad range of topics including digestive physiology, metabolic disorders and specific nutrients such as carbohydrates proteins and lipids, with particular attention being paid to nutritional and metabolic idiosyncrasies. It is an essential text for students of animal and veterinary sciences.

      • Trusted Partner
        Dietetics & nutrition
        July 2010

        Nutrition, Immunity and Infection

        by Prakash Shetty

        Infectious diseases are an important cause of malnutrition. Recurrent infections increase the risk of malnutrition while poor nutritional status results in lowered immune status and predisposes to infectious disease thus propagating the vicious cycle of infection and malnutrition. The nutrition-infection-immunity axis is crucial for both developed and developing countries and is now a central feature of many nutrition and infectious disease courses. Bringing together nutrition and immunology, Nutrition, Immunity and Infections covers the topic in an accessible format for all students of nutrition, medicine and public health. Through his work at the London School of Hygiene and Tropical Medicine, the FAO’s Food and Nutrition Division and his current post at the University of Southampton, Professor Shetty has built a reputation to match his wealth of experience in the relationship between nutrition and susceptibility to infection.

      • Trusted Partner
        Medicine
        December 2021

        Fasciolosis

        by John Pius Dalton

        Fasciolosis is a major global infection of livestock causing both huge losses to the agricultural community and affecting human health as a food-borne disease. Fully updated throughout, this new edition continues to cover the life cycle, biology, and development of the parasite; clinical pathology, immunology, diagnosis and vaccine development; and emergence, cause and mechanisms of drug resistance. It reviews the temperate liver fluke Fasciola hepatica, together with molecular, biochemical, control, and epidemiologial aspects of the tropical liver fluke F. gigantica. Many fundamental advances have taken place in the last two decades, but of particular importance has been the mapping of the draft genome of Fasciola. In addition, comprehensive advances in transcriptomics, proteomics and glycomics have been made, and the book therefore pays particular attention to these developments with the addition of brand-new chapters. Also covering the impact these parasites have had on the global human population, their distribution and their ecology, this book provides a comprehensive and accessible resource for scientists, researchers and students of medical and veterinary parasitology.

      • Trusted Partner
        Dietetics & nutrition
        October 2002

        Nutrition and Immune Function

        by Edited by Philip C Calder, Catherine J Field, Harsharnjit S Gill

        This book provides a review of the roles of specific nutrients in maintaining the immune response and host protection against infection. It also considers the influence of various factors, such as exercise and ageing, on the interaction between nutrition and immune function. The main emphasis is on humans, but comparative mammalian data are also presented.The contents include methods for studying nutrient-immune function interactions, the impact of undernutrition on immune function and infection, the influences of fatty acids, amino acids, antioxidant vitamins, and various minerals on immunity, immunological effects of changes throughout the life cycle, and public health policy implications.

      • Trusted Partner
        Infectious & contagious diseases
        April 2013

        Tuberculosis

        Laboratory Diagnosis and Treatment Strategies

        by Edited by Timothy D McHugh.

        Tuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.

      • Trusted Partner
        2020

        Biogenic Drugs

        Textbook of pharmaceutical biology

        by Prof. Dr. Eberhard Teuscher, Prof. Dr. Ulrike Lindequist and Prof. Dr. Matthias F. Melzig. In collaboration with Dr. Elke Langner, Prof. Dr. Timo Niedermeyer and Dr. Alexander Wenig

        The new Teuscher covers the range of relevant areas of biogenic drug substances and medicinal products. In its time-honoured way, it conveys knowledge about the ■ Nature, origin and processing of crude drugs ■ Structure, biosynthesis and metabolism of the constituents ■ Preparation, pharmacology and use of the active substances ■ Dosage and side effects of the medicinal products derived from them The book deals with both classically produced and genetically engineered antibiotics, hormones, enzymes as well as blood and immunological products. Completely new chapters discuss cytokines, gene therapy, use of stem cells and traditional Chinese medicine. For generations, the textbook and companion for both students and fully qualified professionals!

      • Trusted Partner
        Insects (entomology)
        December 1998

        Tsetse Biology and Ecology

        Their Role in the Epidemiology and Control of Trypanosomosis

        by Stephen G A Leak

        Domestic livestock in Africa are of importance not only as a source of milk and meat but also as a source of animal traction enabling farmers to cultivate larger areas, with crops providing the staple foods. Trypanosomosis, a parasitic disease transmitted cyclically by the tsetse fly (Glossina spp.), is arguably still the main constraint to livestock production on the continent, preventing full use of the land to feed the rapidly increasing human population. Sleeping sickness, the disease caused in humans by species of Trypanosoma, is an important and neglected disease posing a threat to millions of people in tsetse-infested areas. Often wrongly thought of as a disease of the past, the prevalence of human sleeping sickness is increasing in many areas.Although alternative methods to control the disease are being investigated, such as immunological approaches, use of chemotherapy or exploitation of the trypanotolerance trait, it is only control or eradication of the tsetse fly vector which will remove the threat of the disease rather than providing a better means of ‘living’ with it. As a result of the economic impact of tsetse-transmitted Trypanosomosis, a large amount of research literature has been produced. This book provides a comprehensive review of this literature. The text is divided into four parts: tsetse biology and ecology, epidemiology, vector control and control of trypanosomosis. The book is invaluable for medical and veterinary entomologists, parasitologists and epidemiologists.

      • Trusted Partner
        Technology, Engineering & Agriculture
        April 2017

        Fish Viruses and Bacteria

        Pathobiology and Protection

        by Patrick T K Woo, Rocco C Cipriano

        Taking a disease-based approach, Fish Viruses and Bacteria: Pathobiology and Protection focuses on the pathobiology of and protective strategies against the most common, major microbial pathogens of economically important marine and freshwater fish. The book covers well-studied, notifiable piscine viruses and bacteria, including new and emerging diseases which can become huge threats to local fish populations in new geographical regions if transported there via infected fish or eggs. A concise but thorough reference work, this book: - Covers key viral and bacterial diseases of notable fish species; - Reviews major well-established piscine pathogens as well as new, emerging and notifiable diseases; and - Contains the most up-to-date research contributed by a team of over fifty world experts. An invaluable bench book for fish health consultants, veterinarians and all those wanting instant access to information, this book is also a useful textbook for students specializing in fish health and research scientists initiating fish disease research programmes. ; Taking a disease-based approach, this book focuses on the pathobiology of and protective strategies against the most common, major microbial pathogens of economically important marine and freshwater fish. It covers well-studied, notifiable piscine viruses and bacteria, including new and emerging diseases. ; 1: Infectious Pancreatic Necrosis Virus, Arun K. Dhar, Scott LaPatra, Andrew Orry and F.C. Thomas Allnutt 2: Infectious Haematopoietic Necrosis Virus, Jo-Ann C. Leong and Gael Kurath 3: Viral Haemorrhagic Septicaemia Virus, John S. Lumsden 4: Epizootic Haematopoietic Necrosis and European Catfish Virus, Paul Hick, Ellen Ariel and Richard Whittington 5: Oncogenic Viruses: Oncorhynchus masou Virus and Cyprinid Herpesvirus, Mamoru Yoshimizu, Hisae Kasai, Yoshihiro Sakoda, Nanako Sano and Motohiko Sano 6: Infectious Salmon Anaemia, Knut Falk and Maria Aamelfot 7: Spring Viraemia of Carp, Peter Dixon and David Stone 8: Channel Catfish Viral Disease, Larry A. Hanson and Lester H. Khoo 9: Largemouth Bass Viral Disease, Rodman G. Getchell and Geoffrey H. Groocock 10: Koi Herpesvirus Disease, Keith Way and Peter Dixon 11: Viral Encephalopathy and Retinopathy, Anna Toffan 12: Iridoviral Diseases: Red Sea Bream Iridovirus and White Sturgeon Iridovirus, Yasuhiko Kawato, Kuttichantran Subramaniam, Kazuhiro Nakajima,Thomas Waltzek and Richard Whittington 13: Alphaviruses in Salmonids, Marius Karlsen and Renate Johansen 14: Aeromonas salmonicida and A. hydrophila, Bjarnheidur K. Gudmundsdottir and Bryndis Bjornsdottir 15: Edwardsiella spp., Matt J. Griffin, Terrence E. Greenway and David J. Wise 16: Flavobacterium spp.: F. psychrophilum, F. columnare and F. branchiophilum, Thomas P. Loch and Mohamed Faisal 17: Francisella noatunensis, Esteban M. Soto and John P. Hawke 18: Mycobacterium spp., David T. Gauthier and Martha W. Rhodes 19: Photobacterium damselae, John P. Hawke 20: Piscirickettsia salmonis, Jerri Bartholomew, Kristen D. Arkush and Esteban M. Soto 21: Renibacterium salmoninarum, Diane G. Elliott 22: Streptococcus iniae and S. agalactiae, Craig A. Shoemaker, De-Hai Xu and Esteban M. Soto 23: Vibriosis: Vibrio anguillarum, V. ordalii and Aliivibrio salmonicida, Alicia E. Toranzo, Beatriz Magariños and Ruben Avendaño-Herrera 24: Weissella ceti, Timothy J. Welch, David P. Marancik and Christopher M. Good 25: Yersinia ruckeri, Michael Ormsby and Robert Davies

      • Trusted Partner
        Medicine
        December 2019

        Nutrition of the Rabbit

        by Carlos de Blas, Julian Wiseman

        Bringing together international expertise in rabbit production, topics covered in this fully updated volume include digestive physiology, feed formulation and product quality, as well as feeding strategies, feed processing, feed management around weaning and the relationship between nutrition and intestinal health. Brand new to this edition, the chapters also discuss the development of immune response and the role of intestinal microbiota, new dietary sources and additives, and feeding behaviour in pasture and organic feeding. A valuable resource for researchers and students of animal nutrition and production, this book provides a comprehensive, research-based review of nutrition for these important animals.

      • Trusted Partner
        Medicine
        August 2018

        Lyme Disease

        An Evidence-based Approach

        by John J Halperin

        This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects. This new edition: Includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection. As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.

      • Trusted Partner
        January 2019

        Hepatitis, Third Edition

        by Alan Hecht, D.C. and Lyle W. Horn, Ph.D.

        Hepatitis means an inflammation of the liver, but it also refers to a group of viral infections that affect the liver. There are several types of viral hepatitis, but the most common are A, B, and C. Viral hepatitis is spread through contact with infected blood, bodily fluids, or feces, though it may also result from alcohol and drug use or from other diseases. Acute hepatitis refers to the initial infection and can be mild or severe; chronic hepatitis refers to a serious condition in which the infection lasts six months or longer. Currently, vaccines are available for the prevention of hepatitis A and B viruses. This third edition of Hepatitis delves into the history, causes, and current treatments for this disease, giving valuable and up-to-date information to student researchers. Chapters include: Introduction to Hepatitis The Phases of Hepatitis Looking at the Liver Inflammation and Immune Response Hepatitis A Hepatitis B Hepatitis C.

      • Trusted Partner
        January 2022

        COVID-19 and Other Coronaviruses, Second Edition

        by Patrick G. Guilfoile, Ph.D.

        In December of 2019, the first reports came from Wuhan, China of a new respiratory infection that was causing serious illness. The cases were initially associated with a market where live animals were being sold for food. By tracing the outbreak, cases were retrospectively identified as early as November 17, 2019 and some undetected cases may have occurred even prior to that time. The first death from this new illness was reported on January 11, 2020. Since then this disease has spread across the globe achieving pandemic status and disrupting contemporary life. This new volume in the Deadly Diseases and Epidemics series, COVID-19 and Other Coronaviruses, Second Edition, traces the history of coronaviruses, past outbreaks of coronavirus-related illnesses, such as SARS, and explains the nature of SARS-CoV-2, the virus behind COVID-19. It also includes a new chapter dedicated to the emerging SARS-CoV-2 variants that are appearing. Other chapters include: History of Coronaviruses Testing for and Diagnosis of Coronavirus Infections Transmission of Coronavirus Diseases Molecular Biology and Immunology of Coronavirus Diseases Prevention of COVID-19 and Other Coronavirus Diseases Outlook for COVID-19 and the Potential for Future Coronavirus Pandemics

      • Trusted Partner
        January 2020

        Tuberculosis, Third Edition

        by Alan Hecht, D.C.

        Tuberculosis is a serious infection caused most commonly by the Mycobacterium tuberculosis bacterium or one of three other organisms of the Mycobacterium genus. Tuberculosis primarily affects the lungs, but the infection can attack any part of the body. If left untreated, tuberculosis can cause lung damage, meningitis, and even death; the World Health Organization reported 1.5 million deaths due to tuberculosis in 2018. Those at highest risk for tuberculosis include those with weakened immune systems and those in areas of the world with poor nutrition and poor access to health care. Most cases of tuberculosis can be treated with a combination of medications that are taken for several months, but failure by many people to fully follow their course of treatment has led to the emergence of drug-resistant strains of tuberculosis bacteria. Tuberculosis, Third Edition covers the history, causes, and treatments of this potentially deadly disease. Chapters include: Tuberculosis Throughout Time Robert Koch, Selman Waksman, and the Near Defeat of Tuberculosis The Tuberculosis Bacterium Consumption: What Happens Once You Become Infected Transmission from Organism to Organism The Immune Response to Tuberculosis Infection Screening for and Diagnosis of Tuberculosis The BCG Vaccine Treatment of Tuberculosis I: Sanatoriums and Early Drug Treatments Treatment of Tuberculosis II: Modern Drug Therapy The Human Immunodeficiency Virus and Tuberculosis

      • Trusted Partner
        Medicine
        September 2018

        Nutrition and Feeding of Organic Poultry

        by Robert Blair

        Organic poultry production has increased significantly in recent years to keep up with increasing consumer demand for organic eggs and meat. There are many guidelines and restrictions on what should go into the feed of organically-farmed poultry, from which difficulties arise when trying to ensure a well-balanced nutritious diet without the use of any unapproved supplements. This, the second edition of Robert Blair's classic and bestselling book on the nutrition and feeding of organic poultry, presents advice for organic producers, and the agencies and organizations serving them. It covers: - Selecting suitable ingredients. - Preparing appropriate feed mixtures and integrating them into organic poultry production systems. - International standards for organic feeding. - Breeds that are most suitable for organic farming. - Examples of diets formulated to organic standards. Completely updated and revised to address how to formulate organic diets in situations where there is a declining supply of organic feed, this new edition also includes up-to-date information on the nutritional requirements of poultry and feed-related disease incidence in organic flocks. Also including the feasibility of utilizing novel feed, such as insect meal, and their acceptability by consumers of organic meat products, this book forms a comprehensive reference for students, organic farmers, veterinarians and researchers.

      • Trusted Partner
        January 2020

        Hantavirus Pulmonary Syndrome, Second Edition

        by Alan Hecht D.C. and Stephanie Leuenroth

        Hantavirus pulmonary syndrome (HPS) is a deadly disease transmitted by infected rodents through urine, droppings, or saliva. Humans can contract the disease when they breathe in the virus from the air. In Hantavirus Pulmonary Syndrome, students will learn about the symptoms of this disease, as well as the effects, treatment, and history of HPS, which was first recognized in 1993 and has since been identified throughout the United States. Although rare, it is potentially deadly, and awareness is the first step toward prevention. Chapters include: History of Hantavirus Pulmonary Syndrome (HPS) Hantavirus Mechanisms of Infection by Hantavirus Immune Response to Hantavirus Transmission of Hantavirus Diagnosis and Treatment of Hantavirus Pulmonary Syndrome (HPS) Epidemiology of Hantaviruses Preventing Exposure to Hantavirus Hantavirus Pulmonary Syndrome (HPS) and Prospects for the Future

      • Trusted Partner
        Science & Mathematics
        March 2017

        The Handbook of Microbial Metabolism of Amino Acids

        by J P F D'Mello, K Abe, M I Afzal, M Akhtar, J M P Alves, R Balana Fouce, Q Bashir, R A Bender, Simon Brown, Catherine Cailliez-Grimal, R William Caldwell, Barbara Campanini, Yingying Cao, Trinad Chakraborty, D Charlier, N P Chowdhury, O O Coker, Daniela de Biase, Stephane Delaunay, Renwick C J Dobson, Mike F Dunn, D Fulton, Fabio Giovannercole, D E Holmes, A.O Hudson, Y Kera, G D Kornfeld, F Leroy, Z Liao, Rob D Locy, J S Lott, Patrick M Lucas, R Lucas, P Ludovico, J M Moran, A Mozzarelli, A J Nieuwkoop, N Osorio, John V Paietta, Prasit Palittapongarnpim, Emily J Parker, A Parthasarathy, F G Pearce, Eugenia Pennacchietti, Y Perez-Pertejo, R S Phillips, N Rashid, P J Quinn, F Rodrigues, M J Romero, B Sampaio-Marques, M A Savka, K Shibata, David C Simcock, H V Simpson, J A Smith, S Takahashi, Saleh Umair, X Wang, Matthew J Wargo, S Watanabe, Freya Wencker, W Ziebuhr, I W Dawes

        This book collates and reviews recent advances in the microbial metabolism of amino acids, emphasizing diversity - in terms of the range of organisms under investigation and their natural ecology - and the unique features of amino acid metabolism in bacteria, yeasts, fungi, protozoa and nematodes. As well as studying the individual amino acids, including arginine, sulfur amino acids, branched-chain amino acids and aromatic amino acids, a number of themes are explored throughout the work. These include: - Comparative issues between the metabolism of microbes and those of higher organisms, including plants and mammals - Potential for drug targets in pathways of both biosynthesis and degradation of amino acids - Relationship between amino acids or associated enzymes and virulence in parasitic pathogens - Practical implications for food microbiology and pathogen characterization - Future priorities relating to fundamental biochemistry of microrganisms, food quality and safety, human and animal health, plant pathology, drug design and ecology As the volume of research into the metabolism of amino acids grows, this comprehensive study of the subject is a vital tool for researchers in the fields of biological, medical and veterinary sciences, including microbiology, biochemistry, genetics and pathology. This book is also essential for corporate organizations with active research and development programmes, such as those in the pharmaceutical industry. ; This book collates and reviews recent advances in the microbial metabolism of amino acids, emphasizing diversity - in terms of the range of organisms under investigation and their natural ecology - and the unique features of amino acid metabolism in bacteria, yeasts, fungi, protozoa and nematodes. ; -: PrefacePART I: GLUTAMATE1: Structural and Functional Properties of Glutamate Dehydrogenases2: Glutamate Decarboxylase in Bacteria3: The Yeast GABA ShuntPART II: LYSINE, ARGININE AND HYDROXYPROLINE4: Lysine Biosynthesis in Microorganisms5: Arginine Deiminase in Microorganisms6: Arginase and Microbial Pathogenesis in the Lungs7: Arginine and Methionine as Precursors of Polyamines in Trypanosomatids8: Ornithine and Lysine Decarboxylation in Bacteria9: The Role of Nitric Oxide Signalling in Yeast Stress Response and Cell Death10: Hydroxyproline Metabolism in MicroorganismsPART III: SERINE AND THREONINE11: Cellular Responses to Serine in Yeast12: Threonine Degradation in Hyperthermophilic OrganismsPART IV: SULFUR AMINO ACIDS13: Methionine Synthesis in Microbes14: Regulation of Sulfur Amino Acid Metabolism in Fungi15: Insight on O-Acetylserine Sulfhydrylase Structure, Function and Biopharmaceutical ApplicationsPART V: BRANCHED-CHAIN AMINO ACIDS16: Metabolic Engineering of Corynebacterium glutamicum for L-Valine Production17: Flavour Formation From Leucine by Lactic Acid BacteriaPART VI: AROMATIC AMINO ACIDS AND HISTIDINE18: Microbial Degradation of Phenolic Amino Acids19: The Biosynthesis of Tryptophan20: Tryptophan Biosynthesis in Bacteria: Drug Targets and Immunology21: The Kynurenine Pathway of Tryptophan Metabolism in Microorganisms22: Histidine Degradation in Bacteria23: Histidine Phosphatase Superfamily in Pathogenic BacteriaPART VII: D-AMINO ACIDS24: Functions and Metabolism of D-Amino Acids in Microorganisms25: Pathways of Utilization of D-Amino Acids in Higher OrganismsPART VIII: ECOLOGY26: Rhizobial Amino Acid Metabolism: Polyamine Biosynthesis and Functions27: Working Together: Amino Acid Biosynthesis in Endosymbiont-Harbouring Trypanosomatidae28: Amino Acid Metabolism in Helminths29: Microbial Degradation of Amino Acids in Anoxic Environments30: Utilization of N-Methylated Amino Acids by Bacteria31: Biofilm Formation: Amino Acid Biomarkers in Candida albicans32: Recent Advances Underpinning Innovative Strategies for the Future

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