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      • Immunology
        January 2014

        Virus-like Particles in Vaccine Development

        by Franco Buonaguro, Luigi Buonaguro

        Alternative strategies to vaccines based on live attenuated or inactivated pathogens are constantly being developed with an aim to increase safety without significant loss of immunogenicity. Among these, virus-like particles (VLPs) offer several valuable features and represent a very appealing model. The eight timely and in-depth chapters of this book have been contributed by leaders in the field and cover a range of current topics in VLP-based vaccine development and clinical assessment for a range of human infectious diseases.

      • Immunology
        October 2011

        Current & Emerging Diagnostics, Therapeutics & Vaccines for Tuberculosis

        by Stefan HE Kaufmann

        New tuberculosis (TB) strategies are needed if we want to bring the threat of TB to an end in the 21st century. This book focuses on the salient issues of TB control by medical strategies: diagnostics, therapeutics and vaccines. By concentrating on the salient features of new and current intervention measures against TB, this book gives the reader a concise update on TB control by medical means. Each chapter of this book is written by experts in their respective fields.

      • Immunology
        December 2011

        Addressing Unmet Medical Needs in Relapsing–Remitting Multiple Sclerosis

        by Richard A Rudick, Robert Bermel

        More than two decades since the first disease-modifying therapies became available to treat MS, the field of MS therapeutics is evolving faster than ever. The first injectable disease-modifying therapies brought hope and help to those fighting a previously untreatable disease. One chapter of the book is devoted to emerging oral therapies as a therapeutic modality – an approach that is more accessible and can improve compliance relative to the injectable approaches that are still used worldwide as first-line treatment. As more treatments for RRMS emerge, there will be a greater need to base treatment decisions on disease or biological characteristics in individual patients. Monoclonal antibodies and antigen-receptor therapies are examples of how the potential exists to suppress MS disease activity through a variety of different mechanisms of action. In addition, one of the most important new frontiers is development of strategies for neuroprotection and neurorepair. Novel biological pathways and therapeutics are also being explored for their ability to enhance innate repair mechanisms and remyelination.

      • Immunology
        March 2012

        Emulsion-based Vaccine Adjuvants

        by Steven G Reed, Christopher Fox, Darrick Carter

        Emulsions are the next most widely used adjuvants in human vaccines after alum-based formulations. Their importance in modern vaccines is underscored by their demonstrated record of stability, safety, and enabling of antigen dose-sparing. The book includes an introduction addressing a historical perspective and exploring currently available adjuvants. The book then profiles two leading emulsion adjuvants for human use: MF59® (Novartis) and AS03 (GlaxoSmithKline) and concludes with an overview of innovations in technology covering next-generation emulsions. Together, the chapters in this volume provide a snapshot of emulsion adjuvant history, current human use and safety, and future development directions.

      • Immunology
        April 2014

        Advances in Anaphylaxis Management

        by Denise Anne Moneret-Vautrin

        Anaphylaxis is an acute, life-threatening allergic reaction that is now recognized as a global health problem. Observed at all ages, its prevalence is strikingly increasing in the pediatric population, and lethal risk may be underestimated owing to a lack of diagnosis in fatal cases with rapid onset, and the absence of a specific code in the International Classification of Diseases. The nine chapters of this book provide a state-of-the-art overview, exploring the causes and manifestations of anaphylaxis and highlighting issues in diagnosis, prevention, monitoring and management.

      • Immunology
        February 2014

        Current Approaches to Allergic Rhinitis

        by Cristoforo Incorvaia

        Allergic rhinitis is one of the most common diseases and currently affects not less than 15–20% of the general population, with prevalence steadily increasing both in children and adults. It is often considered of negligible medical importance, but a number of aspects oppose this perception, including the relevant economic impact and the significant impairment of the patient’s quality of life. This book provides practitioners with the information to appropriately manage this common and underestimated disease. The five chapters provide a broad overview of our current understanding of allergic rhinitis, including clinical presentation, pathogenesis, diagnosis and treatment.

      • Immunology
        December 2013

        Microbial Drug Resistance

        by Vladimir Krcméry

        We face the prospect of physicians in hospitals trying to treat patients infected by multidrug-resistant organisms that are unresponsive to all available antibiotics. This book of twelve chapters addresses the threats of antibiotic resistance and the potential transition into a postantibiotic era. Internationally renowned experts have provided an extensive overview exploring current and emergent pathogen challenges, measures to prevent antimicrobial resistance and the direction of future research.

      • Immunology
        July 2013

        Personalized Management of Multiple Sclerosis

        by Bianca Weinstock-Guttman, Murali Ramanathan, Robert Zivadinov

        Multiple sclerosis is a highly heterogeneous disease with a dissimilar disease course and a different response to therapies among individual patients. Although a cure for MS is still a distant prospect, the disease will be manageable in most patients with appropriate therapies. The most important challenge regarding these therapeutic interventions will be to tailor the therapy to the needs of the patients and the severity of the disease. This book of thirteen concise chapters provides an expert perspective on the disease and its treatment in different individuals and future prospects and directions for research and therapy.

      • Immunology
        February 2014

        Novel Approaches in Immunoassays

        by Hannu Koistinen, Ulf-Håkan Stenman

        In recent decades, immunoassays have become widely used for the sensitive and specific investigation of a variety of different analytes, from proteins to steroids, drugs and microbes. In the five chapters of this book, immunoassay experts first establish the general principles of immunoassay before highlighting new developments, especially in the area of assay technology. The book illustrates the versatility of immunoassays and emphasizes how one type of assay is not suitable for all applications. The authors place the technology in context and explore pros and cons, recognizing that novel assays are still needed for many purposes (e.g., healthcare, forensics, environmental and food analysis).

      • Immunology
        March 2012

        Emerging Oral Medications for Multiple Sclerosis

        by Sten Fredrikson, Jan Hillert

        In the past two decades we have experienced a profound change in our view of multiple sclerosis. Nevertheless, we are still only at the beginning of a new era for treatment of the disease. This book, in four sections written by acknowledged experts, first addresses the unmet medical needs associated with available treatments. The second chapter is a thorough exploration of potential pathogenetic mechanisms that could be targeted with new oral medications. In the third chapter, oral immunomodulators in late-stage clinical trials are described, and the final chapter deals with oral therapeutics in the pipeline and future directions for therapeutic approaches, including some symptomatic therapies and hypothetical strategies for promoting CNS protection and repair.

      • Immunology
        March 2012

        Pneumococcal Conjugate Vaccines

        by Ger T Rijkers

        Streptococcus pneumoniae (the pneumococcus) is a pathogen with significant disease implications, especially for the (very) young and the (very) old. It causes mucosal infections such as otitis media and pneumonia but also causes invasive diseases such as bacteremia and meningitis. In this book of seven chapters, international experts address the major challenges facing the current use and future development of pneumococcal conjugate vaccines – both from the scientific and the political standpoint. As such, the book comprises a comprehensive and up-to-date overview of this rapidly evolving field.

      • Immunology
        November 2011

        Plant-derived Vaccines: Technologies & Applications

        by Franco M Buonaguro

        This book includes 11 chapters spanning most of the issues involved in plant-based vaccine production, including intellectual property considerations and veterinary applications. In addition to the detailed description of antigen expression in different plant systems, adjuvant production and plant glycosylation of proteins are also analyzed.

      • Complementary medicine

        NeuroIntegrative Medizin

        Durch körpereigene Intelligenz die Selbstheilungskräfte aktivieren

        by Gerlinde Debus und Meike Scheuplein

        Unser Körper ist ein hochfunktionales und sehr komplexes Energiesystem, das im permanenten Informationsaustausch mit der inneren und äußeren Welt steht. Alle Körpersysteme kommunizieren untereinander und sind über Nervenverbindungen mit dem Gehirn vernetzt, das als übergeordnete Instanz Millionen von Zellen und jede einzelne Funktion unseres Organismus steuert. Unser Gehirn weiß also in jedem Augenblick über alle Vorgänge und Zustände in unserem Körper genau Bescheid. NeuroIntegrative Medizin ist eine moderne Therapie, die dieses hochdynamische Kommunikationsnetzwerk und dessen körpereigene Intelligenz nutzt, um die beschwerdeauslösenden Störungen in den Informationskreisen von Organen, Gelenken, Gewebe und Gehirn aufzuspüren. Über gezielt gesetzte Reize wird eine Korrektur der Fehlschaltungen initiiert. Das versetzt unseren Körper in die Lage, seine autonome Steuerung wieder herzustellen und die Erkrankung ursächlich und nachhaltig selbst zu heilen. Professor Dr. med. Gerlinde Debus und Dr. med. Meike Scheuplein, Therapeutinnen mit langjähriger Erfahrung in der NeuroIntegrativen Medizin, eröffnen einen tiefen Einblick in die erstaunliche Wirkweise dieser modernen Therapiemethode, die uns helfen kann, aus eigener Kraft gesund zu werden. Behandlungsbeispiele aus dem Praxisalltag veranschaulichen, wie die Körperintelligenz die Selbstheilungsprozesse aktiviert und welche Chancen und Optionen diese Therapieform bei akuten wie auch chronischen Erkrankungen bietet. NeuroIntegrative Medizin

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