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      • Trusted Partner
        Human Microbiota and Microbiome
        Medical microbiology & virology
        May 2014

        Human Microbiota and Microbiome

        by Markus Egert, Wim Crielaard, Larry Forney, Ken Bruce, Huiying Li, Takahiro Matsuki, Tom van de Wiele, Andrew Goodman, Marco Ventura, Jia Li, Elaine Holmes. Edited by Julian R Marchesi.

        Thousands of different microbial species colonize the human body, and are essential for our survival. This book presents a review of the current understanding of human microbiomes, the functions that they bring to the host, how we can model them, their role in health and disease and the methods used to explore them. Current research into areas such as the long-term effect of antibiotics makes this a subject of considerable interest. This title is essential reading for researchers and students of microbiology.

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      • Trusted Partner
        Bacterial Pili
        Medical microbiology & virology
        April 2014

        Bacterial Pili

        Structure, Synthesis and Role in Disease

        by Edited by Michele A Barocchi, John L Telford

        Bacterial pili play important roles as environmental sensors, in host colonization and in biofilm formation, enabling bacteria to interact with the environment, with surfaces and with other bacteria and host cells. Most bacteria, both Gram positive and Gram negative, and almost all bacterial pathogens, are piliated. This book discusses the synthesis, structure, evolution, function and role in pathogenesis of these complex structures, and their basis for vaccine development and therapeutics for Streptococcus pathogens. It is an invaluable resource for researchers and students of medical microbiology.

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      • Trusted Partner
        Antimicrobial Peptides
        Medical microbiology & virology
        November 2010

        Antimicrobial Peptides

        Discovery, Design and Novel Therapeutic Strategies

        by Edited by Guangshun Wang.

        Antimicrobial Peptides (AMPs) are an organism's built-in defence molecules that have attracted extensive research attention worldwide. Harnessing and creating them synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. In addition to covering the current advances in AMP research, this volume examines new technologies such as bioinformatics, combinatorial libraries, high-throughput screening, peptidomimetics, biophysics, and structural biology. This volume also describes new methods and strategies for AMP prediction, design, and applications that overcome obstacles in developing them into therapeutic agents.

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      • Trusted Partner
        Helicobacter pylori in the 21st Century
        Medical microbiology & virology
        June 2010

        Helicobacter pylori in the 21st Century

        by Steffen Backert, Stefan Bereswill, Tom Blanchard, Pelayo Correa, Richard Ferrero, Kwong-Ming Fock, Sara Lindén, Hoda Malaty, Barry Marshall, Francis Megraud, Anthony P Moran, John Nedrud, Karen Robinson, Maria Kaparakis. Edited by Philip Sutton, Hazel Mitchell.

        Helicobacter pylori is a globally significant pathogen that infects half of the population of the world. Its recognition enabled the development of new therapeutic and preventative strategies for serious health conditions such as gastric cancer, of which it is the major causative agent. Providing a broad overview of the current understanding of this pathogen and emphasising its world health impacts, this book explores a range of topics including virulence factors, vaccine development and obstacles, epidemiology, antibiotic resistance and the role of Nod receptors, with a foreword by Barry Marshall, the Nobel Laureate and co-discoverer of H. pylori. It is an essential resource for researchers, students and medics in infectious and Helicobacter-associated diseases.

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      • Trusted Partner
        Antimicrobial Stewardship
        Medicine
        December 2016

        Antimicrobial Stewardship

        Principles and Practice

        by Kerry LaPlante, Cheston Cunha, Haley Morrill, Louis Rice, Eletherios Mylonakis

        In an age where antimicrobial resistance amongst pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection. This single comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection. Amongst the first of its kind, this book provides infectious disease physicians, administrators, laboratory, pharmacy, nursing and medical staff with practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration. ; Antimicrobial research has hit a wall: treatment discoveries are rarer and resistant pathogen strains more prevalent. Rather than infection control itself, antimicrobial stewardship is an essential measure in ensuring management of hospital-acquired infections. Throughout this book, international experts discuss all angles of stewardship. ; Part I: Overview of Antibiotic StewardshipCh.1: Principles of Antimicrobial StewardshipCh 2: Clinical Perspective of Antimicrobial StewardshipCh 3: History of Antimicrobial StewardshipCh 4: The Importance of Education in Antimicrobial StewardshipPart II: Antibiotic Resistance Principles in Antibiotic Stewardship Ch 5: Intrinsic and Acquired Mechanisms of ResistanceCh 6: Antimicrobial Resistance: Selection vs. InductionCh 7: Colonization and its importance for emergence of clinical resistanceCh 8: Antibiotic Resistance: associations and implications for antibiotic usage strategies to control multi-resistant bacteriaPart III: Microbiology Laboratory Role in Antibiotic StewardshipCh 9: The role of active surveillance in the prevention of healthcare-acquired infections and antibiotic stewardshipCh 10: Role of Antibiogram in Antibiotic StewardshipCh 11: Selective Reporting and Antimicrobial StewardshipCh 12: Role of New Diagnostics to Enhance Antibiotic Stewardship EffortsPart IV: Infection Control Aspects of Antibiotic StewardshipCh 13: Epidemiology of S aureus and enterococci in children and an overview of antimicrobial resistanceCh 14: Epidemiology of multi-drug resistant gram-negative organismsCh 15: Pathogenesis and Epidemiology of Clostridium difficile Infection: Implications for Antibiotic StewardshipCh 16: Role of the Hospital Epidemiologist in Supporting Antimicrobial StewardshipPart V: Pharmacokinetic (PK) & Pharmacodynamic (PD) Aspects of Antibiotic Dosing in Antibiotic StewardshipCh 17: Principles of Pharmacokinetic / Pharmacodynamic Optimization for Antibiotic DosingCh 18: Optimal use of Gram-negative antibiotics in the real world: providing effective therapy while minimizing resistanceCh19: Optimal Use of FluoroquinolonesCh 20: Optimal Use of Beta-lactam AntibioticsCh 21: Current Approach to Optimal Use and Dosing of Vancomycin in Adult PatientsCh 22: Principles of IV to PO SwitchPart VI: Pharmacy Department Role in Antibiotic StewardshipCh 23: Role of Pharmacists in Antimicrobial StewardshipCh 24: Formulary Management and Economic Considerations; Bridging the Gap between Quality Care and CostCh 25: Approaches in benchmarkingCh 26: Development and execution of stewardship interventionsCh 27: Technologic support for antimicrobial stewardshipPart VII: Measuring Outcomes in Antibiotic Stewardship ProgramsCh 28: Role of Guidelines and Statistical Milestones for Antimicrobial StewardshipCh 29: Economic considerations of Antimicrobial Stewardship ProgramsCh 30: Pharmacoeconomic Implications of Antimicrobial Adverse EventsCh 31: Antimicrobial stewardship programs in areas of increased pathogen resistancePart VIII: Antimicrobial Stewardship and Various Practice SitesCh 32: Role of Antimicrobial Stewardship in PediatricsCh 33: Antimicrobial Stewardship in the Intensive Care UnitCh 34: Role of Antimicrobial Stewardship in a Community HospitalCh 35: Outpatient Parenteral Antimicrobial Therapy (OPAT)Ch 36: The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship: Immersion of Future Healthcare ProfessionalsCh 37: Antimicrobial Stewardship and the Importance of Working with the Government and Pharmaceutical IndustryCh 38: Hospitalist Perspective on the Role of Antimicrobial Stewardship

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      • Trusted Partner
        Antimicrobial Peptides
        Medicine
        September 2017

        Antimicrobial Peptides

        Discovery, Design and Novel Therapeutic Strategies

        by Guangshun Wang

        Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.

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      • Trusted Partner
        Bacterial Pili
        Medicine
        September 2019

        Bacterial Pili

        Structure, Synthesis and Role in Disease

        by Michele A Barocchi, John L Telford

        Bacterial pili play important roles as environmental sensors, in host colonization and in biofilm formation, enabling bacteria to interact with the environment, with surfaces and with other bacteria and host cells. Most bacteria, both Gram positive and Gram negative, and almost all bacterial pathogens, are piliated. This book discusses the synthesis, structure, evolution, function and role in pathogenesis of these complex structures, and their basis for vaccine development and therapeutics for Streptococcus pathogens. It is an invaluable resource for researchers and students of medical microbiology.

        More
      • Trusted Partner
        The Human Microbiota and Microbiome
        Medicine
        September 2019

        The Human Microbiota and Microbiome

        by Julian R Marchesi

        Thousands of different microbial species colonize the human body, and are essential for our survival. This book presents a review of the current understanding of human microbiomes, the functions that they bring to the host, how we can model them, their role in health and disease and the methods used to explore them. Current research into areas such as the long-term effect of antibiotics makes this a subject of considerable interest. This title is essential reading for researchers and students of microbiology.

        More
      • Trusted Partner
        Metabolomics and Systems Biology in Human Health and Medicine
        Medicine
        September 2019

        Metabolomics and Systems Biology in Human Health and Medicine

        by Oliver A.H. Jones

        The metabolomics and systems biology approach to research can be applied to many disciplines. This book provides a solid introduction to medical metabolomics and systems biology, and demonstrates how they have been applied to studies in medicine and human health, including nutrition and pathogenic microorganisms. Following core themes of diagnosis, pathology and aetiology of disease, this book provides a reference for health care professionals interested in how to use metabolomics for medical research.

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