Epistola publishing house is a family-owned company founded in 2009. We seek to provide quality reading with variety of themes to enrich the lives of young readers. Our books have distinctively educational purpose, inspiring discussion with parents, teachers or other children. In order to provide the best possible reading and achieve quality, we collaborate with renowned domestic and foreign authors.
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Singapore's largest independent publisher of fiction and non-fiction for all ages. Check out our latest catalogue here: July – December 2018 (PDF.)
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This book is contemporary, topical and global in its approach, and provides an essential, comprehensive treatise on bovine tuberculosis and the bacterium that causes it, Mycobacterium bovis. Bovine tuberculosis remains a major cause of economic loss in cattle industries worldwide, exacerbated in some countries by the presence of a substantial wildlife reservoir. It is a major zoonosis, causing human infection through consumption of unpasteurised milk or by close contact with infected animals. Following a systematic approach, expert international authors cover epidemiology and the global situation; microbial virulence and pathogenesis; host responses to the pathogen; and diagnosis and control of the disease. Aimed at researchers and practising veterinarians, this book is essential for those needing comprehensive information on the pathogen and disease, and offers a summary of key information learned from human tuberculosis research. It will be useful to those studying the infection and for those responsible for controlling the disease.
Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations. This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described. Concluding with a review of ethical issues and a framework for translating human genomics research to clinical practice and public health benefit, this textbook is an essential new resource for graduate students in epidemiology and public health genetics.
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Lyme borreliosis commonly known as lyme disease is now acknowledged as the most highly prevalent arthropod-borne human disease in northern temperate regions of the world. This book describes the basic characteristics of the disease, the biology of the pathogens in their vectors and vertebrate hosts, their ecology in different regions of the world and the global epidemiology of the disease. The final chapters address the prevention and control measures that have resulted from this knowledge.
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Understanding parasite biology and impact is essential when giving advice on parasite control in farm animals. In the first review devoted to parasites of domestic cattle and sheep alone, this book provides in-depth, focused advice which can be tailored to individual farms. It considers the impact of parasites, both as individual species and as co-infections, as well as epidemiological information, monitoring, and diagnostic procedures. Supported throughout by diagrams and photos to aid diagnosis, it also reviews the basis for control measures such as the responsible use of parasiticides, adaptive animal husbandry and other management practices. This book: Focuses on common parasites of domestic sheep and cattle; Places emphasis on understanding host responses and epidemiology so that the impact and seasonality of parasitism can be incorporated into advice and decision making; Highlights the fundamental importance of the individual farm and farmer in assessing endemic parasitism and tailoring control options accordingly; Provides a comprehensive reference listing, including important historical citations, to underpin the content. An important resource for students, veterinarians and researchers of farm animal health, this book maintains a focus on ruminant parasitology in order to deliver evidence-based advice and also context for the application of basic research.
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Gonorrhea is a common sexually transmitted disease. More than 700,000 people are infected annually in the United States, according to the Centers for Disease Control and Prevention. It is curable with antibiotic treatment, and its dangerous effects can be prevented if it is identified and treated early in its development. Gonorrhea, Third Edition looks at the disease from historical and epidemiological perspectives, describing the discovery of the bacterium that causes gonorrhea, how it can be prevented, and the development of effective treatments. Chapters include: What Is Gonorrhea? History of Gonorrhea and Sexually Transmitted Diseases Symptoms and Diagnosis of Gonorrhea Epidemiology of Gonorrhea Complications and Treatment of Gonorrhea The Future of Gonorrhea.
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Caused by a virus that is spread through the bite of an infected mosquito, yellow fever gets its name for the jaundice it causes its victims. This hemorrhagic illness has plagued humans throughout history, and before the development of a yellow fever vaccine, the mortality rate from this disease was high. Tropical nations now prevent epidemic yellow fever levels through vaccination, and travelers to these areas are advised to take precautions. Yellow Fever, Second Edition explores both the historical and epidemiological aspects of this disease. Colorful photographs, maps, and illustrations provide important explanations of various aspects of yellow fever, and information on vaccination, treatment, prevention, and up-to-date statistics on worldwide incidences are provided. Chapters include: The Yellow Fever Disease Disease Course and Epidemiology Diagnosis, Treatment, and Prevention Yellow Fever and Other Modern Plagues The Impact of Diseases on History Future Directions in Controlling Viral Diseases.
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The fungal genus Ganoderma includes around 80 currently recognized species that are widely distributed in temperate, subtropical and tropical regions, and cause disease in a range of economically important perennial crops and tree-like plants. Ganoderma root and lower stem rots have a significant impact on yields from crops including oil palm, coconut, beverage crops, Acacia and rubber. The identification of species responsible for stem and butt rots is often ambiguous as closely related species may only be distinguished by subtle morphological differences. Within species there can be considerable morphological plasticity and this can make morphology-based identification difficult, particularly for species described from a single specimen. Molecular techniques are helping to slowly resolve Ganoderma taxonomy but it will be some time (if ever) before the taxonomy is fully resolved. This book brings together information on Ganoderma species that are reported to be responsible for crop diseases in tropical and sub-tropical agriculture and covers taxonomy, biology, genetics, aetiology, epidemiology and control. This book is an essential resource for researchers in Ganoderma in crop science and tropical agriculture, as well as practitioners and industry.
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First recorded in Europe in the late 1400s, syphilis quickly spread throughout the world. A disease that slowly kills its victims, syphilis allows them enough time to spread it to others. It was not until the 19th century that syphilis was realized to be a sexually transmitted disease. Because syphilis was poorly understood, it became the subject of many myths and misconceptions, and people who suffered from the disease were often stigmatized. Syphilis, Third Edition looks at the disease from historical and epidemiological perspectives, describing the discovery of the bacterium that causes syphilis as well as the medical advances that shed light on how the disease spread, how that spread could be prevented, and the development of effective treatments. Chapters include: The Disease Called Syphilis History and Folklore of Syphilis Syphilis: From Plague to STD Treponema: The Syphilis Organism Prevention and Treatment of Syphilis Epidemiology of Syphilis Syphilis in Contemporary Society A Case Study in Syphilis Research.
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Paratuberculosis, also referred to as Johne's disease, affects cattle, goats, sheep, buffalo, deer and other ruminants. Examining the epidemiology of paratuberculosis, the organism that causes the disease, and practical aspects of its diagnosis and control, the book also addresses the link between paratuberculosis in the food chain and human health implications, including Crohn's disease. This timely new edition: - builds on a strong foundation to update, streamline and better structure existing chapters with important new developments from the last decade; - includes new chapters discussing the fast-growing field of whole genome based comparative genomics, and the increasing opportunities for disease control in low- and middle-income countries; - Brings on board rising star new authors from diverse backgrounds to include varied perspectives. A truly comprehensive, critical reference resource, this book is an essential reference for large animal veterinarians, livestock industry personnel and those involved in the dairy and meat industries, as well as microbiologists, researchers and students in these fields.
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This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects. This new edition: Includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection. As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.
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In an age where antimicrobial resistance amongst pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection. This single comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection. Amongst the first of its kind, this book provides infectious disease physicians, administrators, laboratory, pharmacy, nursing and medical staff with practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration. ; Antimicrobial research has hit a wall: treatment discoveries are rarer and resistant pathogen strains more prevalent. Rather than infection control itself, antimicrobial stewardship is an essential measure in ensuring management of hospital-acquired infections. Throughout this book, international experts discuss all angles of stewardship. ; Part I: Overview of Antibiotic StewardshipCh.1: Principles of Antimicrobial StewardshipCh 2: Clinical Perspective of Antimicrobial StewardshipCh 3: History of Antimicrobial StewardshipCh 4: The Importance of Education in Antimicrobial StewardshipPart II: Antibiotic Resistance Principles in Antibiotic Stewardship Ch 5: Intrinsic and Acquired Mechanisms of ResistanceCh 6: Antimicrobial Resistance: Selection vs. InductionCh 7: Colonization and its importance for emergence of clinical resistanceCh 8: Antibiotic Resistance: associations and implications for antibiotic usage strategies to control multi-resistant bacteriaPart III: Microbiology Laboratory Role in Antibiotic StewardshipCh 9: The role of active surveillance in the prevention of healthcare-acquired infections and antibiotic stewardshipCh 10: Role of Antibiogram in Antibiotic StewardshipCh 11: Selective Reporting and Antimicrobial StewardshipCh 12: Role of New Diagnostics to Enhance Antibiotic Stewardship EffortsPart IV: Infection Control Aspects of Antibiotic StewardshipCh 13: Epidemiology of S aureus and enterococci in children and an overview of antimicrobial resistanceCh 14: Epidemiology of multi-drug resistant gram-negative organismsCh 15: Pathogenesis and Epidemiology of Clostridium difficile Infection: Implications for Antibiotic StewardshipCh 16: Role of the Hospital Epidemiologist in Supporting Antimicrobial StewardshipPart V: Pharmacokinetic (PK) & Pharmacodynamic (PD) Aspects of Antibiotic Dosing in Antibiotic StewardshipCh 17: Principles of Pharmacokinetic / Pharmacodynamic Optimization for Antibiotic DosingCh 18: Optimal use of Gram-negative antibiotics in the real world: providing effective therapy while minimizing resistanceCh19: Optimal Use of FluoroquinolonesCh 20: Optimal Use of Beta-lactam AntibioticsCh 21: Current Approach to Optimal Use and Dosing of Vancomycin in Adult PatientsCh 22: Principles of IV to PO SwitchPart VI: Pharmacy Department Role in Antibiotic StewardshipCh 23: Role of Pharmacists in Antimicrobial StewardshipCh 24: Formulary Management and Economic Considerations; Bridging the Gap between Quality Care and CostCh 25: Approaches in benchmarkingCh 26: Development and execution of stewardship interventionsCh 27: Technologic support for antimicrobial stewardshipPart VII: Measuring Outcomes in Antibiotic Stewardship ProgramsCh 28: Role of Guidelines and Statistical Milestones for Antimicrobial StewardshipCh 29: Economic considerations of Antimicrobial Stewardship ProgramsCh 30: Pharmacoeconomic Implications of Antimicrobial Adverse EventsCh 31: Antimicrobial stewardship programs in areas of increased pathogen resistancePart VIII: Antimicrobial Stewardship and Various Practice SitesCh 32: Role of Antimicrobial Stewardship in PediatricsCh 33: Antimicrobial Stewardship in the Intensive Care UnitCh 34: Role of Antimicrobial Stewardship in a Community HospitalCh 35: Outpatient Parenteral Antimicrobial Therapy (OPAT)Ch 36: The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship: Immersion of Future Healthcare ProfessionalsCh 37: Antimicrobial Stewardship and the Importance of Working with the Government and Pharmaceutical IndustryCh 38: Hospitalist Perspective on the Role of Antimicrobial Stewardship
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Globally, the way the animal production industry copes with infectious diseases is changing. The (excessive) use of antimicrobials is under debate and it is becoming standard practice to implement thorough biosecurity plans on farms to prevent the entry and spread of pathogenic micro-organisms. Not only in farm animal production, but also in facilities where companion animals are kept, including in veterinary practices and clinics, awareness of the beneficial implications of a good biosecurity plan has raised. The book Biosecurity in Animal Production and Veterinary Medicine is the first compilation of both fundamental aspects of biosecurity practices, and specific and practical information on the application of the biosecurity measures in different animal production and animal housing settings. The book starts with a general introductory chapter on the epidemiology of infectious diseases, followed by a chapter explaining the general principles of biosecurity. Specific topics of biosecurity, including rodent and insect control, cleaning and disinfection, hygiene and decontamination of feed, drinking water and air, and measuring the biosecurity status of farms, are detailed in dedicated chapters. Explanations on the relevance of the implementation of biosecurity plans in order to improve animal health and performance and reduce antimicrobial usage are described, and a chapter on ways to motivate farmers to implement a biosecurity plan has been included. Practical chapters deal with biosecurity in the poultry, pig and cattle industry, horse facilities, dog kennels, veterinary practices and clinics and laboratory animal facilities. The book is a practical guide that can be used by farm and animal facility managers, consultants, veterinarians, animal caretakers, and people with an interest in prevention of diseases in animals. Academics and students will benefit from the book because it contains all relevant information on animal biosecurity.
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A little-known deadly disease called toxic shock syndrome quickly became a top news story when scientists discovered its prevalence in some women who used a particular type of tampon during menstruation. Today, the disease continues to emerge under new circumstances. Toxic Shock Syndrome, Third Edition investigates the causes and history of toxic shock syndrome and discusses the severity of septic diseases. Chapters include: Toxic Shock Syndrome: A "New" Disease Septic Disease and Body Defenses Staphylococcal Toxic Shock Syndrome Streptococcal Toxic Shock Syndrome Epidemiology of Toxic Shock Syndrome Diagnosis and Treatment Toxic Shock and Feminine Hygiene.
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Meningitis is an inflammation of the meninges, the protective covering that surrounds the brain and spinal cord. Most commonly caused by a viral infection, it may also result from infection with bacteria or fungus. Bacterial meningitis is usually more severe than viral meningitis and can lead to hearing loss, learning disabilities, and brain damage. If not treated promptly, it can be deadly. Meningitis, Third Edition contains the most current information on the causes, spread, treatment, and prevention of the disease, as well as illustrations and case studies. Chapters include: Meningitis: A Silent Disease Bacterial Meningitis Viral Meningitis Other Types of Meningitis Epidemiology Diagnosis, Treatment, and Prevention.
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Rabies is a remarkable virus with a long history. Most often transmitted to humans via the bite of a rabid animal, the disease travels through the nervous system to the brain, where it replicates and eventually causes death. While rabies is treatable if detected early, there is no treatment after symptoms appear. Today rabies continues to be a significant health concern, especially in underdeveloped countries where it causes thousands of deaths per year. Complete with statistics and trends, Rabies, Second Edition provides a thorough analysis of this dangerous disease, from prevention and treatment to recent research and developments.Chapters include: Stages of Rabies Infection Epidemiology of Rabies Diagnosing Rabies Prevention, Vaccination, and Treatment of Rabies.
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Pneumonia is a major lung infection that is caused by a virus, bacterium, or fungus. It can be mild, serious, or even fatal in its impact. Millions of people develop pneumonia in the United States annually, and despite ready access to antibiotics for most Americans, 1.3 million patients are hospitalized for pneumonia each year, according to the Centers for Disease Control and Prevention. About 50,000 people in the United States die each year of pneumonia. Pneumonia, Second Edition explains the causes, symptoms, diagnosis, and treatment of this serious disease. Chapters include: An Overview Historical Background Biology of Pneumonia: Source of the Infection Pneumonia Epidemiology Complications from Pneumonia Diagnosis, Treatment, and Prevention.
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The herpes simplex virus belongs to a family of viruses known as the Herpesviridae. Herpes viruses, of which there are eight, are widespread in the human population, and symptoms of these viruses range from mild blisters to painful skin lesions. Herpes simplex virus type 1 causes cold sores, while herpes simplex virus type 2 causes genital herpes. Treatment drugs cannot cure herpes, but they can shorten or prevent outbreaks. Herpes, Second Edition describes the symptoms, diagnosis, treatment, and prevention of these viruses, as well as the newest research. Chapters and topics include: A Painful Discovery Epidemiology of Sexually Transmitted Diseases Nature's Design: Virus Structure Virus Replication Lying in Wait: Virus Latency Clinical Syndromes Diagnosis and Treatment Prevention and Control The Future of Herpes.
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Rubella and rubeola were once commonly thought of as childhood diseases, but these viral infections pose a threat to children and adults alike. These illnesses had been largely brought under control in developed nations through widespread vaccinations, but in recent years there have been outbreaks due to an increased number of people refusing vaccination and parents refusing to vaccinate their children. Although both diseases are known commonly as the measles, the viruses that cause them are not closely related. "German measles" (rubella) is caused by rubivirus, and the red measles (rubeola) is caused by morbilivirus. Rubella and Rubeola, Second Edition takes a look at the history, pathology, potential complications, prevention, and treatment of these diseases. Chapters include: An Ancient Plague Viral Diseases Rubeola: The Red Measles Rubella: The "German Measles" Epidemiology Diagnosis, Treatment, and Prevention Future Directions in Controlling Viral Diseases.
