This companion to "The Business of Plant Breeding: Market-led Approaches to Plant Variety Design in Africa contains experiences from postgraduate educators training the next generation of African plant breeders and professional breeders that are implementing best practices in Demand-Led Breeding (DLB) in their current crop improvement programmes. It is written by highly experienced plant breeders representing several universities, national plant breeding programmes, regional and international agricultural research institutes in Africa, together with expert breeders from Australia and developers from private seed companies. It includes specifically points of learning from real implementation situations from crop breeding programmes in NARS and IARCs in Africa, Australia and internationally. It shares experiences on improving tropical crops, strengthening understanding on how to overcome challenges in designing new crops to increase smallholder farmer adoption and advocating best practices. It also presents five case studies on tropical crops, and discusses the need for an enabling policy environment and the changes needed for Africa to achieve its ambition for food security and Africa's vision 2063.