The past two decades have seen substantial advances in the understanding of chronic lymphocytic leukemia (CLL), including new insights from genetics and molecular biology regarding the heterogeneity in clinical behavior observed in this disease. The Editors highlight how vast and complex the CLL has become, but foresee a new dawn for physicians and researchers seeking to better understand and treat the disease. In reflecting on these advances, the eight chapters of this book from international experts address key issues in understanding CLL, its current management and future prospects for treatment. Topics include diagnosis & staging, genetics of disease, treatment options and chemotherapy, stem cell transplantation, options in refractory disease, prognostic factors and future directions for management.