Epistola publishing house is a family-owned company founded in 2009. We seek to provide quality reading with variety of themes to enrich the lives of young readers. Our books have distinctively educational purpose, inspiring discussion with parents, teachers or other children. In order to provide the best possible reading and achieve quality, we collaborate with renowned domestic and foreign authors.
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Singapore's largest independent publisher of fiction and non-fiction for all ages. Check out our latest catalogue here: July – December 2018 (PDF.)
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This book provides a state-of-the-art overview of current achievements and future possibilities for the application of epigenetic and epigenomic techniques to the improvement of crops. Creating crops more resilient to the stresses caused by climate change will be an important part of a climate-smart and sustainable agriculture strategy for the future. All critical environmental stressors are explored: temperature, salt, drought, pollutants, pests, fungi, bacteria, and viruses. The exciting possibilities for the integration of epigenetic resources and technologies with plant functional genomics and the new field of precision molecular breeding in crops are discussed. Examples are shown of crops showing better growth performance, enhanced yields, more efficient nutrient utilization, and higher quality food production. The book reviews all aspects of epigenetics, epigenomics, and emerging RNA technologies and presents fundamental and advanced tools, showing their current applications in plant sciences, plant functional genomics, plant stress physiology, plant biotechnology, plant pathology, and plant breeding. The ethical, moral, and societal issues raised by these new plant breeding technologies are also discussed and future challenges are debated. This book is an ideal complete guide for students, researchers, experts, and professionals to overview this critical topic.
The rapid progress in molecular genetic techniques and molecular biology has led to a great expansion in the range of biotechnology applications in agriculture. The field is supported by a large number of basic and applied sciences, and agricultural biotechnology has become a multidisciplinary field. A vast amount of technical terms is required to be grasped by students, teachers and research workers and this new Glossary of Agricultural Biotechnology covers all the scientific areas in this important field, including agricultural biotechnology, artificial intelligence, bioinformatics, biostatistics, cell biology, computer science, CRISPR/Cas, cytogenetics, DNA nanotechnology, epigenetics, epigenomics, genetics, genome editing, genomics, intellectual property rights, molecular biology, molecular genetics, nanobiotechnology, plant breeding, plant pathology, plant physiology, remote sensing, therapeutics, and tissue culture. The book includes: · Common abbreviations in agricultural biotechnology · Brief descriptions and definitions of each term written in a user-friendly style · A comprehensive bibliography. This book is designed to be an easy-to-use reference for students, teachers, research workers, workers in biotechnology-related government agencies, and the biotechnology industry.
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This book summarises the impacts that the genome sequencing revolution has had in all areas across animal and plant agriculture, including cattle, orphan crops, cash crops, and more, with reference to applications in many species and locations. It explains new techniques and their use in understanding epigenetics, breeding and conservation.
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This practical book introduces “nature-based therapy” (NBT) as a newer therapeutic approach to the treatment of stressrelated illnesses. The authors, with many years of experience in the felds of psychosomatics and garden therapy, use NBT as an extension of garden therapy and landscape medicine. They present the theoretical foundations and justify the use of nature as a therapeutic space. They show how the therapeutic approach can be applied in the felds of stress research, psycho neuroimmunology, epigenetics, personality psychology, and lifestyle research. In 20 case descriptions they present the use of concrete therapy modules and describe each module with preparatory nature anamnesis, core topics, goals, materials and exercises.
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Plant gene silencing is a crucially important phenomenon in gene expression and epigenetics. This book describes the way small RNA is produced and acts to silence genes, its likely origins in defence against viruses, and also its potential to improve plants. Plant gene silencing can be used to improve industrial traits, make plants more nutritious or more valuable to consumers, to remove allergens, and to improve resistance to weeds and pathogens ; Chapter 1: Diversity of RNA silencing pathways in plantsChapter 2: Induction and suppression of silencing by plant virusesChapter 3: Artificial induction and maintenance of epigenetic variations in plantsChapter 4: Gene Silencing in Archaeplastida AlgaeChapter 5: Gene silencing in fungi: A diversity of pathways and functionsChapter 6: Artificial small RNA-based strategies for effective and specific gene silencing in plantsChapter 7: Application of RNA silencing in improving plant traits for industrial useChapter 8: Increasing nutritional value by RNA silencingChapter 9: RNA-based control of plant diseases: a case study with Fusarium graminearumChapter 10: Targeting nematode genes by RNA silencingChapter 11: Gene silencing provides efficient protection against viruses
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Today, we live in a new, anthropogenic environment that differs signifcantly from the environments to which we have adapted in the course of our evolution. This has signifcant effects on us humans, our health, and our social interaction. But how does the complex interaction between humans and the environment work from an evolutionary perspective? How does evolution affect our biology and behavior? What role do genetic and epigenetic aspects play here? And what inflence does this have on the development of diseases such as diabetes mellitus type 2, cardiovascular diseases, allergies, autoimmune diseases or mental disorders? The book attempts to provide answers to these complex questions and allows an exciting evolutionary view of our future with new approaches for individual lifestyle opportunities, but also for future public health measures.
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Completely updated and revised, and synthesizing the recent explosion in animal welfare literature, the sixth edition of this best-selling textbook continues to provide a thorough overview of behaviour and welfare of companion and farm animals, including fish. The introductory section has been completely revised, with all following chapters updated, redesigned and improved to reflect our changing understanding. This edition includes: - New and revised chapters on climate change and sustainability, ethics, and philosophy to ensure that the book provides the latest information in a changing world; - New information on human interactions with other animal species, big data, modern technologies, brain function, emotions and behaviour; - Solutions and advice for common abnormal behaviours. Written by a world-leading expert and key opinion leader in animal behaviour and welfare, this text provides a highly accessible guide to the subject. It is an essential foundation for any veterinary, animal science, animal behaviour or welfare-focused undergraduate or graduate course.
Every time you look in the mirror you see a mystery of biology. Each cell in your body carries exactly the same genetic code, and yet you don’t have teeth growing out of your eyeballs and you never get toenails coming out of your liver. How can one blueprint lead to so many different final structures? Epigenetics. It’s the fastest moving field in modern biology, yet very little has been written on this for a general readership. Now is the perfect time for such a book – not only do we know many examples of epigenetics in action, we’re finally starting to understand the mechanisms of how it works.
New Clinical Genetics continues to offer the most innovative case-based approach to modern genetics. It is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counselors, physician assistants, and clinical and nurse geneticists. In the few years since the previous edition technical progress, especially the widespread use of whole-genome technologies, has brought many advances in the understanding, diagnosis and treatment of genetic disease. As a result, most chapters have been substantially rewritten and updated to reflect this. The unique structure and format remains the same, but significant new material has been added to cover: the widespread use of next-generation sequencing as a routine diagnostic tool the checking of a patient’s whole exome for the cause of their problem noninvasive prenatal diagnosis by next-generation sequencing of free fetal DNA in the maternal circulation a new integrated treatment of epigenetics mosaicism, ‘RASopathies’ and disorders of the spliceosome are described in new Disease boxes dysmorphology in more detail
You Are What Your Grandparents Ate takes conventional wisdom about the origins of chronic disease and turns it upside down. Rooted in the work of the late epidemiologist Dr. David Barker, it highlights the exciting research showing that heredity involves much more than the genes your parents passed on to you. Thanks to the relatively new science of epigenetics, we now know that the experiences of previous generations may show up in your health and well-being.To learn more about this publisher, click here: http://bit.ly/2Kj7j3d
Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms. To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.
Break free from the patterns that hold you back and achieve new heights of success with a groundbreaking approach to constellations work. Transformational and systemic coach Judy Wilkins-Smith says, “While everyone knows that we inherit our physical DNA from our ancestors, few people realize that we also inherit multiple generations of patterns of decisions, thoughts, feelings, actions, and mindsets—an ‘emotional blueprint’ that is deeply unconscious, yet faithfully repeated.” According to Wilkins-Smith, one of the most effective ways to shift these unconscious, inherited patterns is by working with systems dynamics and constellations. Here she makes the profound implications of these models immediately accessible to anyone searching for personal healing and transformation. Drawing from neuroscience, epigenetics, genealogy, and quantum physics, Wilkins- Smith shares a variety of strategies and practices that will help you detect hidden and multigenerational patterns, recognize their purpose, and then break the cycles, to create an extraordinary life.
The integration of biology, genomics, and health has opened the possibility of applying genomics technology to nutrition. In 2001, scientists associated with the Human Genome Project announced the successful mapping of the reference sequence of the human genome. Since then, a body of information has emerged. Genomics and related areas of research have contributed greatly to efforts to understand the cellular and molecular mechanisms underlying diet-disease relationships. Integration and application of genetic and genomics technology into nutrition research is, therefore, needed to develop nutrition research programs that are aimed at the prevention and control of chronic disease through genomics-based nutritional interventions. Of interest is the integration of relevant computational methods into nutritional genomics research; the enhancement of tools applicable to systems biology; and the effective dissemination of genomics-derived information to scientists, policy makers, and the interested public. To address these issues, a workshop was held on June 1 and 2, 2006. The workshop included presentations that were structured around three focus sessions: human genetic variation, epigenetics, and systems biology. A fourth session presented discussions on the implications of nutrigenomics for the future of nutrition science research. Numerous themes emerged from the workshop presentations. First, nutrigenomics is a complex field because it addresses issues related to multigenetic traits that can be modified by a number of nutritional and other environmental factors. Such complexity presents a challenge to the field; and the ensuing research opportunities will require cooperative work among scientific disciplines and across government, academic, and industrial centers, as well as adequate funding, to be realized. Additionally, the ability to stretch the limits of conventional research methodologies afforded by new genetic and genomic applications at the level of the individual opens the door to a wealth of potential benefits to areas such as disease prevention and wellness, bearing in mind the necessity of ethical safeguards. This potential, however, must be wisely exploited to avoid the pitfalls of overpromising research results and prematurely setting unrealistic expectations for beneficial outcomes. Finally, careful and rigorous research must be employed to optimize outcomes and assure acceptance by the scientific community. In summary, nutrition science is uniquely poised to serve as the crossroads for many disciplines and, using genomics tools, can bring this knowledge together to better understand and address diet-related chronic diseases and molecular responses to dietary factors.
إِنَّ تطور العالمين الحي و اللاحي هو تطور جزيئي موجه، حدث بفعل القوى الطبيعية الأربع (الثقالة، والنوويتان القوية والضعيفة، والكهرطيسية)، وبفعل القوة الطبيعية الخامسة المقترحة (الاستبقائية). ولقد استلزم هذا الفعل للقوى الطبيعية الخمس التوافق التام والأنيق للثوابت الطبيعية كي تحافظ على بنية الكون، وعلى تطور مادته. وحدث هذا التوجيه من قبل القوى الطبيعية الخمس، وبسبب التوافق التام للثوابت الطبيعية، كي تتحقق خاصيتا الأناقة والحكمة، اللتان التزم التطور بتحقيقهما. ولقد حدث هذا التحقق بفعل الاستبقائية (القوة الطبيعية الخامسة)، التي حافظت —عبر ثابتة الترابط (Ka)— على ما انجزته الطبيعة من مادة وطاقة حرة؛ فصانت الاستبقائية المادة —كما نعرفها— ضد فعل التعدمية. كما صانت الاستبقائية أيضاً الطاقة الحرة (–?G) ضد فعل الشوش. أَمَّا النظرية المقترحة الثانية؛ فتتمثل في أَنَّ الجينوم البشري (شأنه في ذلك شأن جينوم الثديات كافة، وربما شأن جينومات جميع الفقاريات، أو حتى اللافقاريات بدرجات تتناقص بوضوحها)، يتألف من قسمين، أو نمطين: نمط جيني (وراثي genotype) يخصص النوع البشري، ويميِّزه عن أي نوع ثديي آخر. ونمط بعد جيني epigenotype يناوع الفرد البشري. ويكوِّن الأول النمط الظاهري الجيني genophenotype البشري؛ بينما يكوِّن الثاني النمط الظاهري بعد الجيني epigenetic phenotype. إِنَّ قرابة 1.5 في المئة فقط من DNA خلايانا يكوِّن نحو 24100 جيناً، موجودة في كل أفراد النوع البشري، هي هي ذاتها، منذ 300 ألف عام (حين ظهر الإنسان العاقل)، وحتى الآن. هي هي نفسها بغض النظر عن عرق الإنسان أو سلالته. إنها مسؤولة عن كوننا بيولوجياً بشراً. لكل منا (ويبلغ عددنا الآن أكثر من ستة مليارات نفساً بشرية) التركيب التشريحي البيولوجي العام نفسه، والخصائص الفيزيولوجية والعصبية والتوالدية والمناعية ذاتها. إِنَّها خلال بشرية النوعية، تخصص النوع البشري بجميع أفراده، وتجعله مختلفاً عن أي نوع ثديي آخر. إِنَّ هذه الخلال الخاصة بالنوع البشري فصلته عن القردة العليا الحالية (وبخاصة الشيمپانزي) قبل ما يقرب من 12 مليون عاماً. وتُعرف هذه الجينات بالجينات البشرية المرمزة للبروتينات، أو ببساطة الجينات البشرية. أَمَّا القسم الأعظم من جينومنا (قرابة 98.5 في المئة)؛ فيختلف —في غالبيته— من فرد بشري إلى آخر. ويناوع هذا القسم الفرد البشري على نحو يختلف من إنسان إلى آخر. إِنًّ هذا القسم من جينومنا يجعل جينوم كل فرد منا جينوماً شخصياً. ويتآذر هذا التباين في بنية DNA مع تحويرات فيزيائية وكيميائية تصيب تسلسلات DNA غير المرمزة للبروتينات (تسلسلات DNA، التي هي خارج تسلسلات الجينات البشرية). وتصيب هذه التحويرات أيضاً الهستونات الخمسة، التي تشكل مع DNA صبغياتنا الثلاثة والعشرين؛ فتجعل جينوم كل واحد منا جينوماً شخصياً. وهذا ما يعرف بما بعد الوراثيات epigenetic، ويكوَّن النمط الظاهري بعد الجيني epigenetic phenotype. ويتمثل هذا القسم الشخصي من جينومنا بتسلسلات DNA، التي ترمز أنواعاً من RNA لا علاقة لها بإنشاء البروتينات (أي لا علاقة لها بِـ mRNA، و بِـ rRNA، و بِـ tRNA، التي لها جينات بشرية النوعية ضمن الجينات 24100). ونذكر —كأمثلة من بين هذه الأنواع من RNA الفردية النوعية— RNA مزدوج الشريطة (dsRNA)، و RNA الاعتراضي القصير (siRNA)، أو RNA المُسكت (sRNA). ونذكر من تسلسلات DNA الفردية النوعية تسلسلات المعززات، وتسلسلات المحولات الريبية، وتسلسلات عناصر DNA المتحركة، وتسلسلات الجينات الكاذبة، والتبصيم الجينوم، وهلَّم جرَّا. وغنِيٌّ عن التأكيد أَنَّ معظم ما بعد النمط الجيني يُنظِّمُ تعبير الجينات البشرية نفسُها. أَمَّا في ما يتعلق بالتحويرات الفيزيائية والكيميائية، التي تصيب كلاً من DNA والهستونات، وتجعل جينوم كل فرد منا جينوماً شخصياً؛ فتتمثل خاصة بتمتيل، وبهدروكسي تمتيل DNA. كما تتمثل باستلة الهستونات، وفسفرتها، وكذلك بدرجة ارتزام حلزون DNA، وجسيماته النووية nucleosomes، وهلَّم جرَّا. يمكننا أن نلخص جوهر النظرية الثانية المقترحة بقولنا إِنَّ كثرة التباينات الفردية في تسلسلات القسم الأعظم (98.5 في المئة) من DNA جينومنا، وكذلك التحويرات الفيزيائية والكيميائية، التي تصيب كامل الجينوم، وتصيب أيضاً الهستونات، وتحدث على نحو يختلف قليلاً أو كثيراً من فرد بشري إلى آخر؛ إِنَّ كثرة هذه التباينات، وكثرة هذه التحويرات، التي ينظم معظمها تعبير الجينات البشرية تنظيماً يختلف من فرد إلى آخر، جعلت من جينوم كل فرد بشري جينوماً شخصياً؛ كينونة متفردة، لن ينشأ احتمالياً مثيل indentical لها (باستثناء توأم البيضة الواحدة) طوال عمر النوع البشري (الإنسان العاقل)؛ أي منذ 300 ألف عام، وحتى انقضاء 4.6 مليار عام (عندما تندثر الحياة على الأرض). وللدلالة على ذلك نسوق المثال، الذي ذكر غير مرة: إٍنَّ تكوّْن معقد القحف-الوجه (في الفأر) يحدث نتيجة فاعلية 300 جيناً فأرية (تخصص نوع الفأر). وتنظم فاعلية هذه الجينات الفأرية أربعة آلاف شدفة من DNA، تعمل كلها كمعززات (أي غير مرمزة للبروتينات). أي أَنَّ عدد الأشكال المُحتملة لمعقد القحف-الوجه في الفأر يبلغ ثلاثة مئة مرفوعاً للأس 4000 (4000300). إِنَّ التماثل بين جينوم الإنسان، وجينوم الفأر يزيد على 85 في المئة. وكما سبق أن ذكرنا، وفي ما عدا العقل، والقانون الأخلاقي؛ فإِنَّ الإنسان لا يختلف اختلافاً جوهرياً عن أي ثديي آخر. لذا؛ فأننا نتوقع أن يكون عدد الأشكال الاحتمالية لمعقد القحف-الوجه في الإنسان مساوٍ على الأقل لما هو عليه في الفأر: 4000300؛ أي رقم 3 متبوعاً بأربعة آلاف ومئة صفراً. وتجدر الإشارة إلى أَنَّ عدد الذرات، التي تشكل الكون القابل للرصد يساوي 8010×1 ذرة تقريباً؛ أي رقم 10 متبوعاً بثمانين صفراً فقط.
Gaucher disease is an inborn error of metabolism due to a deficiency of the lysosomal enzyme glucocerebrosidase and is the most common of approximately 40 hereditary lysosomal storage disorders. Although the disease was first described over 125 years ago, it has taken more than 100 years to find an effective therapy. The genetic, epigenetic, biochemical, metabolic and environmental elements that contribute to the marked phenotypic heterogeneity associated with GD remain an important challenge with significant implications for basic research, clinical management, and patient and family counseling. This book of 16 chapters authored by international experts fully explains current understanding of Gaucher disease and explore its characterization, diagnosis and the therapeutic options available.
Winner of the inaugural Interim 2018 Test Site Poetry Series Prize, Refugia is a bright and hopeful voice in the current conversation about climate change. Kyce Bello’s stunning debut ponders what it means to inhabit a particular place at a time of enormous disruption, witnessing a beloved landscape as it gives way to, as Bello writes, “something other and unknown, growing beyond us.” Ultimately an exploration of resilience, Refugia brings to life the author’s home ground in Northern New Mexico and carefully observes the seasons in parallel with personal cycles of renewal and loss. These vivid poems touch upon history, inheritance, drought, and most of all, trees—be they Western conifers succumbing to warming temperatures, ramshackle orchards along the Rio Grande, or family trees reaching simultaneously into the past and future.Like any wilderness, Refugia creates a terrain that is grounded in image and yet many-layered and complex. These poems write us back into an ecological language of place crucial to our survival in this time of environmental crisis.
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This book is a comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. In the setting of a rapidly changing field like oncology, this timely text focuses on mechanisms of action and biological rationale rather than current specific clinical recommendations, allowing current and future clinicians to adapt treatment approaches as our understanding of the biology of cancer evolves. With each chapter written by experts in their field, this book provides informative figures that convey this biological understanding and rationale of therapy. It starts from the mechanisms of treatment as we currently understand them, covering radiation therapy, chemotherapy options, enzyme therapy, gene editing, inhibitors, and many more. Dispensing vital, detailed and practical information about the different therapeutic strategies available, this book is a vital resource for practicing veterinarians, while also providing students of veterinary oncology with a better understanding of the key differences between different treatment strategies.
Anyone can achieve and mantain a high level of happiness, positive emotions, intelligence, confidence, and sociability which ultimately leads to a better life. Learn to achieve permanent solutions to depression, anxiety, phobias, traumas, learning disabilities, as well as personality, and mental disorders. Based on solid scientific research, you will discover natural therapies that work.
The book entitledis aimed to cater to the growing demand of academia, researchers and commercial ventures. Altogether there are forty four s divided into the following broad sections like 1. Bioinformatics, Genomics and Proteomics, 2. Phylogeny 3. Drug Design and Epigenomics 4. Advanced Computational Tools and Techniques 5. Statistical methods for computational biology, data mining and visualization 6. Socio Economics and Ethics. This book presents the foundations of key problems in computational molecular biology and bioinformatics. It contains basic molecular biology concepts, tools, techniques and ways to measure sequence similarity, presents simple applications of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of gene expression and motif finding. Interestingly, it is attempted to introduce computational biology without formulas that presents the biological and computational ideas in a relatively simple manner. It focuses on computational and statistical principles applied to genomes, and introduces the computational statistics that are crucial for understanding and visualization of problems. This makes the material accessible to Statistician and computer scientists without biological training, as well as to biologists with limited background in Statistics and computer science. Furthermore one has been exclusively devoted to computational biology and computational statistics as applied in biotechnology illustrated with methodology, application and interpretation of results. More than four hundred figures, illustrations and diagrams reinforce concepts and present key results from the primary literature that will be very much useful to grasp on the subject, visualize the output and make right interpretation of the result. The book will be useful for all those working in Biotechnology sector in general and particularly researchers working in the laboratories of ICAR, CSIR, SAUs and many more institutions engaged R&D activities.
WHY SO MUCH OF SCIENCE IS WRONG! Barrie Condon shows that science is broken Science is everywhere, our medicines, our transport, what we eat and drink. Like it or not, we can’t make real progress without it. There’s just one dilemma ... What if there are profound problems with all aspects of scien fi c theory and methods? Could it be that the idea of universal laws underpinning reality is a falsehood and, as a result, we need more and more scien sts, and more and more compu ng power, to produce greater and greater elabora ons of our theories to make them fi t inconvenient experimental data? For the fi rst me, we have a book that dares to summarise these profound concerns in a way that is accessible to the general reader, who lacks a scien fi c background. It also provides a warning to Mankind of the risks we run by not acknowledging the, o en, hollow founda ons on which science is built.
