Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders
Proceedings of a Workshop
by National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neurosciences and Nervous System Disorders, Clare Stroud, Noam I. Keren, Sheena M. Posey Norris, Lisa Bain
Description
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders.
In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.
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https://www.nap.edu/24672
Copyright Information
Copyright year 2017
National Academies Press
The National Academies Press (NAP) publish the reports of the National Academies of Sciences, Engineering and Medicine. They published more than 200 books a year on a wide range of topics.
View all titlesBibliographic Information
- Publisher National Academies Press
- Publication Date December 2017
- Orginal LanguageEnglish
- ISBN/Identifier 9780309455138 / 0309455138
- Publication Country or regionUnited States
- FormatPaperback
- Primary Price 42 USD
- Pages92
- ReadershipProfessional and scholarly
- Publish StatusPublished
- Copyright Year2017
- Dimensions9 X 6 inches
- Reference Code10.17226/24672
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