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      • Trusted Partner
        Humanities & Social Sciences
        May 2016

        The neurologists

        A history of a medical specialty in modern Britain, c.1789–2000

        by Stephen Casper

        The neurologists describes how Victorian physicians located in a medical culture that privileged general knowledge over narrow specialism came to be transformed into the specialised physicians we now call neurologists. Relying entirely upon hitherto unseen primary sources drawn from archives across Britain, Europe and North America, this book analyses the emergence of neurology in the context of the development of modern medicine in Britain. The neurologists thus surveys the patterns of change and modernisation that influenced British medical culture throughout the nineteenth and twentieth centuries. In so doing, it ultimately seeks an account of how neurological knowledge acquired such an expansive view of human nature as to become concerned in the last decades of the twentieth century with the human sciences, philosophy, art and literature.

      • Trusted Partner
        Medicine
        March 2017

        The metamorphosis of autism

        A history of child development in Britain

        by Keir Waddington, Bonnie Evans

        This book is available as an open access ebook under a CC-BY-NC-ND licence. What is autism and where has it come from? Increased diagnostic rates, the rise of the 'neurodiversity' movement, and growing autism journalism, have recently fuelled autism's fame and controversy. The metamorphosis of autism is the first book to explain our current fascination with autism by linking it to a longer history of childhood development. Drawing from a staggering array of primary sources, Bonnie Evans traces autism back to its origins in the early twentieth century and explains why the idea of autism has always been controversial and why it experienced a 'metamorphosis' in the 1960s and 1970s. Evans takes the reader on a journey of discovery from the ill-managed wards of 'mental deficiency' hospitals, to high-powered debates in the houses of parliament, and beyond. The book will appeal to a wide market of scholars and others interested in autism.

      • Neurology & clinical neurophysiology
        March 2012

        Fast Facts: Epilepsy

        by Martin J Brodie, Steven C Schachter, Patrick Kwan

        Fast Facts: Epilepsy is a succinct and practical aid to the diagnosis and treatment of seizure disorders. Contents include: the diagnostic essentials - classification of seizures, conditions that can mimic epileptic seizures, clinical evaluation of the patient and the latest brain-imaging techniques, the principles of drug selection and therapy withdrawal, an up-to-date overview of all 15 antiepileptic drugs on the market, the non-pharmacological options for patients with medically refractory epilepsy, including deep brain stimulation, special considerations for women, elderly people, teenagers and people with learning disabilities, psychiatric morbidities - depression, anxiety and psychosis, the effects of epilepsy on employment, driving, life insurance and lifestyle. The management of patients with epilepsy is a team effort involving medical and social service professionals and the patient's family, friends and co-workers. Primary care providers are at the forefront of care, usually performing the initial evaluation after the first seizure, making dose adjustments to the patient's drug treatment and providing ongoing support. Now in its fifth edition, this ever-popular handbook is a neatly packaged, up-to-date resource for the busy clinician and team, to help investigate, diagnose and successfully treat children and adults with a wide range of seizure disorders.

      • Neurology & clinical neurophysiology
        January 2011

        Fast Facts: Brain Tumors

        by Lauren E Abrey, Warren P Mason

        Despite the availability of many effective treatments, there remains a therapeutic nihilism associated with brain tumors. This highly readable second edition of Fast Facts: Brain Tumors challenges this view, starting from the premise that patients with brain tumors can truly benefit from a thoughtful multidisciplinary approach. This comprehensive handbook covers all the salient features of the various brain tumors and treatment modalities in a way that will be useful to the practicing clinician. This fully updated edition of Fast Facts: Brain Tumors bridges the gap between primary care providers - whose role is pivotal in tumor detection and subsequent patient care - and first-level specialists such as general neurologists and neurosurgeons. Its key message is that selection of the best initial approach for an individual patient will result in the best overall outcome, both in terms of survival and quality of life. Fast Facts: Brain Tumors is specifically for the primary care physician whose role is pivotal in tumor detection and subsequent patient care.

      • Neurology & clinical neurophysiology
        April 2014

        Fast Facts: Multiple Sclerosis

        by Omar Malik, Ann Donnelly, Michael Barnett

        Rapid advances in multiple sclerosis (MS) research have produced diagnostic achievements and new treatments that are helping clinicians diagnose and potentially treat MS in the earliest phases of the disease. It is with this sense of optimism that the authors of Fast Facts: Multiple Sclerosis have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team. Contents: • Epidemiology and genetics • Pathology • The clinical picture • Treatment of relapses and symptoms • Disease-modifying treatment • Emerging therapies • Special MS populations • Lifestyle considerations and the multidisciplinary team • Advanced multiple sclerosis Useful resources

      • Neurology & clinical neurophysiology
        February 2012

        Triptans for Migraine

        by Hans-Christoph Diener, David W Dodick

        The triptans have provided desperately needed acute relief from migraine attacks for millions of patients around the world and have ushered in a new era of scientific discovery in the molecular biology and receptor pharmacology of migraine headache. It is two decades since sumatriptan was designed and approved for the acute treatment of migraine, and there are now seven triptans available, in multiple formulations. This book of seven chapters, from some of the world’s most experienced and expert clinicians and clinician-scientists, contains the latest information on the pathophysiology of migraine headache and the current understanding on the mechanism of action of triptans. It provides an overview of the clinical efficacy of oral triptans and the multiple existing and emerging formulations available for use in those for whom oral medications are not suitable. Safety and tolerability issues are also addressed, together with the use of triptans in special populations such as children, the elderly and pregnant women. The book closes with a summary of treatment recommendations and consensus guidelines.

      • Neurology & clinical neurophysiology
        February 2012

        Analgesics for Cancer Pain

        by Frank Porreca, Tamara King

        Although current pain management techniques are efficacious in many patients, there remain many patients in whom pain is inadequately controlled. This eight-chapter work from internationally recognized experts provides a thorough overview of this challenging and topical issue. The book’s first chapter examines the complexity of clinical cancer pain, the importance of proper assessment for adequate treatment, barriers to effective pain relief and approaches toward better understanding of the patient’s therapeutic needs. Many patients reporting moderate to severe cancer pain are treated with opioid analgesics, and options for such therapies are discussed in following chapters. Various adjuvant analgesics for cancer pain are also addressed and there is discussion of the issue of breakthrough pain, outlining its definition and assessment. The final two chapters address emerging analgesics and future directions.

      • Neurology & clinical neurophysiology
        January 2012

        Advances in Parkinson’s Disease Management

        by Joseph Friedman

        Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the western world, and understanding of this condition has undergone dramatic changes. This book provides an update on current understanding of PD from a clinician’s perspective. The chapters are relatively brief so that they can be easily digested at one sitting, and coverage is wide ranging, addressing both clinical and basic-translational issues. The book covers a range of issues from disease etiology, through explorations of biomarkers and imaging to therapeutic approaches, including dopaminergic and nondopaminergic therapies emerging and future drug treatments, nonpsychiatric therapies and surgical treatments. The penultimate chapter addresses the promise offered by stem cell and gene therapies, and the final chapter explores the current guidelines. These ten chapters from international experts provide accessible and rounded coverage of an extremely significant and challenging disease.

      • Neurology & clinical neurophysiology
        September 2012

        Advances in the Pathogenesis and Treatment of Glioblastoma Multiforme

        by Michael D Prados

        This book provides an expert overview of the disease and its treatment, with contributions from acknowledged experts in the field. The first chapter discusses the new pathologic approaches to diagnose and classify the disease, linking those factors to survival predications. The second chapter defines the current standard of care used to treat newly diagnosed disease. There follows a discussion of newer targeted therapeutic strategies being evaluated in early phase clinical trials. Chapter Four outlines various novel therapeutic strategies including the use of genes, viruses, toxins and vaccines. Finally, there is a description of some of the drug delivery strategies currently being evaluated, in order to better get drug-to-target within the confines of the brain.

      • Neurology & clinical neurophysiology
        April 2014

        Novel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea

        by Patrick Lévy

        Obstructive sleep apnea (OSA) is a well-known public health problem with high prevalence and numerous consequences, including excessive daytime somnolence, cognitive impairment, as well as cardiovascular and metabolic morbidity. In this book of eight chapters, renowned experts provide a rounded overview of OSA, with coverage of epidemiology, pathophysiology, diagnosis, clinical consequences and the treatment options available.

      • Neurology & clinical neurophysiology
        August 2013

        Novel Approaches in Migraine Treatment

        by Hans-Christoph Diener

        Worldwide prevalence of migraine is approximately 15% and it is twice more prevalent in females as in males. Attacks peak between 25 and 55 years of age, thus having severe impact on functionality and productivity, reflected by loss of work days. The book highlights the need to explore new avenues in the treatment of migraine. The ten chapters provide an overview of new and emerging approaches to the treatment of acute migraine attacks and to migraine prevention, including new drugs and drug targets, together with advances in nonmedical treatments.

      • Neurology & clinical neurophysiology
        October 2013

        Novel Insights into Systemic Sclerosis Management

        by Maurizio Cutolo, Vanessa Smith

        Systemic sclerosis is a connective tissue disease with chronic vascular, autoimmune and tissue stromal progressive alterations. It is an orphan disease that is clinically characterized by two hallmarks: Raynaud’s phenomenon and skin involvement followed by a varying prevalence of internal organ involvement. There is an annual disease incidence of 19 per million and prevalence of 19–75 per 100,000. In this book of eighteen chapters, the world’s top experts provide an update on the most recent advances on pathophysiology/etiology, clinical issues, advanced diagnosis and therapy in systemic sclerosis.

      • Neurology & clinical neurophysiology
        December 2013

        Clinical Insights: Chronic Pain

        by Angela Dougall, Robert J Gatchel

        Pain is one of the most prevalent symptoms reported in medical settings and is the most frequent reason for physician consultation. Important advances are now being made in the areas of etiology, assessment, treatment and prevention of chronic pain following a major paradigm shift in medicine. Chronic pain is now viewed as more than a symptom of injury or illness, and is seen as an illness unto itself, raising profound and challenging issues for sufferers, their families and the interdisciplinary pain management team responsible for their treatment. This biopsychosocial perspective is the common thread throughout the fabric of this book, which provides healthcare professionals with a firm foundation in chronic pain definition, prediction, assessment and treatment. The book is authored by recognized experts who also share their experience of pain assessment and management in special populations and of rehabilitation of chronic pain sufferers.

      • Neurology & clinical neurophysiology
        February 2014

        Novel Insights into the Pathophysiology and Treatment of Fibromyalgia

        by Bente Danneskiold-Samsøe, Else Marie Bartels

        Myelodysplastic syndromes (MDS) belong to the most frequently seen malignant diseases of the bone marrow, especially in the elderly. Howver, diagnosis and prognosis are often difficult to establish, and treatment decision-making is hampered not only by the lack of available therapies but also by the lack of understanding of pathophysiology. This book, authored by members of the MDS working groups of the Department of Hematology, Oncology and Clinical Immunology of the Heinrich-Heine University of Düsseldorf (Germany) and the Georg-August University Göttingen (Germany), provides an overview and discussion of the pathophysiological concepts, diagnostic procedures and therapeutic approaches in MDS.

      • Neurology & clinical neurophysiology
        August 2014

        Deep Brain Stimulation: Technology and Applications (Volume 2)

        by Jerrold L Vitek

        Volume II addresses the multiple applications that have now been studied, are currently being explored or have been proposed for treatment with DBS. Starting with PD and evolving through other movement and psychiatric disorders, as well as addiction, epilepsy, obesity, headache and pain, this volume provides a comprehensive overview of the current and potential role of DBS in the treatment of neurological, psychiatric and other disorders. Taken together this two volume set will bring together the basic principles and current understanding of DBS applications and technology, while looking ahead to the future of neuromodulation and the next generation of therapies beyond DBS. This book will give an overview of where DBS stands as a therapy for various disorders and where it is headed.

      • Neurology & clinical neurophysiology
        October 2011

        Advances in Antiepileptic Drug Development

        by Philip N Patsalos

        Epilepsy is among the most common serious neurological conditions and affects at least 50 million people worldwide. Considering that the conventional first-generation antiepileptic drugs took more than 70 years to license, the past 22 years have been truly amazing and there are now more than 20 antiepileptic drugs that can be prescribed on a long-term basis for the management of epilepsy.

      • Neurology & clinical neurophysiology
        February 2013

        Critical Care in Spinal Cord Injury

        by Michael G Fehlings

        Injuries to the spinal cord can be truly devastating for the individual and more widely impose a substantial burden on healthcare funding and resourcing. This book, authored by renowned experts, provides a clear and concise introduction to spinal cord injury with up-to-date information in an ever-evolving field. There are chapters on epidemiology, pathophysiology, assessment, use of imaging technologies, diagnosis and classification, available treatments and prognosis. Longer-term care, rehabilitation and prognosis are also highlighted. The book concludes with an overview of emerging therapies offering promise in terms of outcomes and quality of life for patients with spinal cord injury.

      • Neurology & clinical neurophysiology
        February 2014

        Best Practices in Neurological Care

        by Bruce Ovbiagele

        Best Practices in Neurological Care addresses common neurological disorders, with a firm emphasis on contemporary (yet pragmatic), patient-centered, multi-modal, evidence-based management. In thirteen chapters, renowned specialists with extensive clinical practice experience present the relevant scientific evidence together with prevailing expert consensus guideline recommendations for managing patients. In those areas where evidence is sparse, authors provide their own management recommendations. Areas of controversy and future promise are also discussed. Much of the inpatient and ambulatory management of neurological conditions occurs at the boundaries of neurology with medical disciplines, hence this book is of pragmatic value not only to neurologists in training and practice, but also to others, such as emergency physicians, intensivists, hospitalists, general internists, family practitioners, psychiatrists, physiatrists, neuroradiologists and neurosurgeons.

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