The triptans have provided desperately needed acute relief from migraine attacks for millions of patients around the world and have ushered in a new era of scientific discovery in the molecular biology and receptor pharmacology of migraine headache. It is two decades since sumatriptan was designed and approved for the acute treatment of migraine, and there are now seven triptans available, in multiple formulations. This book of seven chapters, from some of the world’s most experienced and expert clinicians and clinician-scientists, contains the latest information on the pathophysiology of migraine headache and the current understanding on the mechanism of action of triptans. It provides an overview of the clinical efficacy of oral triptans and the multiple existing and emerging formulations available for use in those for whom oral medications are not suitable. Safety and tolerability issues are also addressed, together with the use of triptans in special populations such as children, the elderly and pregnant women. The book closes with a summary of treatment recommendations and consensus guidelines.