In its thirteen chapters, this book highlights advances in our understanding of the nature and underpinnings of stroke – a leading cause of death, disability, dementia and depression. Contemporary knowledge is presented regarding public health burden, pathophysiological types/subtypes, traditional/emerging risk factors and prediction models for primary and secondary stroke. In addition, renowned experts present the scientific evidence and consensus expert guideline recommendations for broadening diagnostic and therapeutic options for managing people with or at risk for stroke. Areas of controversy, gaps in knowledge and promising avenues of future focus for these tests/treatments are also covered. Finally, the successful, systematic, and multidisciplinary, hospital-based application of these test/treatments across the continuum of stroke care to achieve favorable outcomes in the ‘real world’ is reviewed.