Before its eradication, smallpox was responsible for millions of deaths throughout history. The disease is unique to humans, caused by one of two virus variants, Variola major and Variola minor. Early symptoms include fever, fatigue, headache, muscle pain, nausea, and vomiting. After 12 to 15 days, lesions appear in the mouth, and then spread to the skin a day or two later. At this point, the disease can take several different courses. Historically, the overall fatality rate is 30%. This revised edition of Smallpox, Second Edition discusses the history and epidemiology of the disease, plus the amazing story of its eradication. Although the disease has not been seen in its natural form in more than 40 years, the future of smallpox, and its potential use as a biological weapon, are of great concern.

Chapters and topics include:

• History of Smallpox
• Elimination of Smallpox
• Smallpox in the Americas
• The Smallpox Virus
• Symptoms
• Treatment
• Vaccine Development
• The Bioweapons Threat
• New Concerns and Future Prospects.