The book revolves around more than 100 world-famous paintings such as Qingming Shanghe Tu and Mona Lisa, which are interpreted from a scientific perspective. The author not only elaborates and analyzes the scientific content and scientific ideas embodied in famous paintings, but also explores and interprets the ideas of the artist's creation, the techniques and means they used, the application of scientific methods in painting techniques, as well as the visual nerve activities, brain and psychological changes of the viewers in the appreciation of paintings. The book has a broad vision and a quotation, which perfectly represents the blending of science and art. It is an intellectual reading that integrates academic exploration, scientific popularization and artistic appreciation. It has both reading, research and collection value. Whether the reader's cultural background is science, humanity, or art, he can be inspired by the author's interpretation and analysis of painting, re-recognizing the masterpieces of art from a scientific perspective, comprehending the scientific knowledge behind the paintings, and get a beautiful experience in reading.