Volume One concentrates on general principles of science and technology leadership and includes sections on social-scientific perspectives on science and technology leadership; key scientific concepts about leading and innovating in science and technology; characteristics of science and technology leaders and their environments; and strategies, tactics, and tools in science and technology.

Volume Two provides case studies of leadership in science and technology, with sections considering leadership in informal communities of scientists and engineers; leadership in government projects and research initiatives; leadership in industry research, development, and innovation; and finally, leadership in education and university-based research.

By focusing on key topics within 100 brief chapters, this unprecedented reference resource offers students more detailed information and depth of discussion than typically found in an encyclopedia entry but not as much jargon, detail or density as in a journal article or a research handbook chapter. Entries are written in language and style that is broadly accessible, and each is followed by cross-references and a brief bibliography and further readings. A detailed index and an online version of the work enhances accessibility for today's student audience.