Seattle senior citizen, DJ Kelly, and her three best friends and co-owners of the Waterfront Art Gallery, are detecting again. Despite an insistent internal voice that chides her for her risky adventures, DJ is not on the trail—this time to help Darlene, a nurse, who is trying to find a young man who was brought into the emergency room yelling a lot of strange, seemingly meaningless terms, including “CCR5,” and then who disappeared—possibly to the Psych Ward. Darlene has received a cryptic phone call from the young man and doesn’t know where to turn. The four women fling themselves into the search, assisted by their old nemesis, Police Inspector Keohan, and the gallery’s handyman and king of malapropisms—Jerry. But their investigation suddenly takes a dangerous turn and the four ladies find themselves in serious jeopardy. Will they find the young man and unravel the mystery of his apparent mental breakdown before it’s too late? Is he insane? Drugged? Or just pretending? It’s all in the genes—and in this case, they’re “killer genes.”