Description

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

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WW ex JP, CN, KR ; L

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http://www.nap.edu/2078

National Academies Press

National Academies Press

The National Academies Press (NAP) publish the reports of the National Academies of Sciences, Engineering and Medicine. They published more than 200 books a year on a wide range of topics.

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Bibliographic Information

  • Publisher National Academies Press
  • Publication Date January 1993
  • Orginal LanguageEnglish
  • ISBN/Identifier 9780309047869
  • Publication Country or regionUnited States
  • FormatPaperback
  • Primary Price 49 USD
  • Pages374
  • ReadershipProfessional and scholarly
  • Publish StatusPublished
  • Dimensions9 x 6 inches
  • Biblio Notes1993

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