The aim of many current global metabolic profiling studies is to discover and apply new metabolic biomarkers. These may be indicative of the mechanisms of disease or the propensity for it to develop, or may enable diagnosis, patient stratification, and prediction/monitoring of response to therapy. The use of global metabolic profiling in the clinic in the future seems assured, and it seems likely that future application will include novel innovations that will put metabolic profiling into the doctor’s consulting room or even into the hands of the surgeon in the operating theatre. The twelve chapters of this timely book provide a snapshot of the current state of the art in metabolic profiling in the clinic.