This book contains contributions on cystic fibrosis (CF) lung disease from leading international investigators. In eight chapters, they describe exciting progress in each of their respective fields, from pathogenesis through symptomatic treatments to addressing the basic defect. Each describes an iterative process in the best traditions of science; hypotheses being tested, rejected or improved. All of the authors have made major contributions to the cause of CF research and treatment over many years, and in this book the Editors have encouraged them to speculate and to be controversial where necessary, providing genuine insight through their experience and expertise.