Urology & urogenital medicine

Clinical Applications of Renin–Angiotensin System Inhibitors

by Michel Burnier

Description

Several newly identified components of the renin–angiotensin system have provided new insights into the role of the system in cardiovascular and renal physiology. The recent discovery of the renin and pro-renin receptor, the characterization of the ACE-2 enzyme and the identification of several angiotensin II receptors have opened new research avenues in the field. This book provides an overview of related therapeutic approaches such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, direct renin inhibition and explores therapies involving RAS blockers alone and in combination approaches. Separate chapters address the renin–angiotensin system in the context of the heart, kidney and brain. The last chapter of this book addresses new therapeutic strategies involving the renin–angiotensin system, such as agonists of the angiotensin II AT2 receptor or agonists of the ACE-2 enzyme. This book addresses current approaches and gives useful insight into the new approaches that are being uncovered as understanding of the system continues to improve.
Clinical Applications of Renin–Angiotensin System Inhibitors

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