This book provides an expert overview of the disease and its treatment, with contributions from acknowledged experts in the field. The first chapter discusses the new pathologic approaches to diagnose and classify the disease, linking those factors to survival predications. The second chapter defines the current standard of care used to treat newly diagnosed disease. There follows a discussion of newer targeted therapeutic strategies being evaluated in early phase clinical trials. Chapter Four outlines various novel therapeutic strategies including the use of genes, viruses, toxins and vaccines. Finally, there is a description of some of the drug delivery strategies currently being evaluated, in order to better get drug-to-target within the confines of the brain.