Clinical trials remain a cornerstone in the development of medical guidelines and in health policy decision-making. Data provide the foundations of all good clinical research, and advances in collating and using trial data are therefore of prime interest in establishing high-quality clinical research. The increasing use of electronic media, network technologies and powerful computation in the collection and analysis of data can lead to improvements in terms of cost, timelines and capabilities, and also facilitate new trial designs based on social networks, for example, or access to large patient databases. This book presents several new aspects in the management of trial data from the collection to the analysis, including ethical concerns.